Table 3.

Associations of delayed graft function and other clinical characteristics with change in peritubular capillary density in the fully adjusted multivariable model (n=191)

Clinical CharacteristicsMean Change, % (SD)Unadjusted Difference in Change, % (95% Confidence Interval)P ValueDifference in Change Adjusted only for Pretransplant Peritubular Capillary Density, % (95% Confidence Interval)P ValueFully Adjusted Difference in Change, % (95% Confidence Interval)aP Value
Postoperative graft function0.60<0.001<0.001
 Immediate graft function−4.6 (5.2)000
 Delayed graft function−3.9 (4.1)0.5 (−1.4 to 2.5)−3.4 (−4.4 to −2.4)−2.9 (−4.0 to −1.8)
Peritubular capillary density on the preimplantation biopsy, per 1% higher−0.8 (−0.9 to −0.8)<0.001−0.8 (−0.9 to −0.8)<0.001−0.9 (−1.0 to −0.9)<0.001
Donor type
 Neurologically deceased−3.4 (4.9)000
 Living−6.3 (4.5)−2.8 (−4.3 to −1.3)<0.0010.7 (−0.2 to 1.6)0.13−0.0 (−1.0 to 0.9)0.97
 Cardiocirculatory arrest−4.3 (4.2)−1.0 (−3.2 to 1.3)0.41−0.6 (−1.8 to 0.7)0.390.3 (−1.0 to 1.5)0.67
Donor age per 10 yr higher−0.2 (−0.7 to 0.2)0.29−0.2 (−1.6 to 0.2)0.11−0.1 (−0.4 to 0.1)0.33
Rejection0.250.120.74
 Absence of rejection−4.2 (5.1)000
 Rejection−5.2 (4.0)−1.0 (−2.7 to 0.7)−0.7 (−1.3 to 1.5)−0.2 (−1.0 to 0.7)
Donor BP0.470.0030.02
 Normal BP−4.5 (4.9)000
 Donor hypertension−3.8 (4.6)0.7 (−1.2 to 2.6)−1.6 (−2.6 to −0.5)−1.2 (−2.2 to −0.2)
Recipient statin use0.900.150.19
 No statin use at transplant−4.3 (4.9)000
 Statin at time of transplant−4.4 (4.8)−0.1 (−1.5 to 1.3)0.6 (−0.2 to 1.3)0.5 (−0.2 to 1.1)
Biopsy type2.2 (−0.3 to 4.7)0.072.3 (1.0 to 3.6)<0.0011.5 (0.2 to 2.7)0.02
 For cause−6.8 (3.6)
 Surveillance−4.2 (4.9)
KRT before transplantation0.770.050.19
 Dialysis pretransplant−4.3 (4.8)000
 Preemptive transplantation−4.9 (5.5)−0.3 (−2.4 to 1.7)1.1 (−0.0 to 1.2)0.7 (−0.4 to 1.7)
Modality of graft transportation0.030.020.14
 Cold storage−5.1 (4.7)000
 Hypothermic perfusion−3.7 (4.9)1.6 (0.2 to 2.9)0.9 (0.1 to 1.6)0.5 (−0.2 to 1.3)
cv score on the pretransplant biopsy, per 1 point higher0.2 (−0.6 to 1.0)0.620.7 (−0.1 to 1.4)0.090.6 (−0.2 to 1.3)0.12
Time to post-transplant biopsy, per 1 mo higher0.2 (−0.3 to 0.7)0.420.3 (0.1 to 0.6)0.010.0 (−0.2 to 0.3)0.85
  • cv, Banff score for vascular fibrous intimal thickening.

  • a In addition to the variables included in the table, estimates are adjusted for biopsy size to correct for technical variations in measurement.