Table 2.

Relative beneficial effect of various interventions on kidney volume and function in polycystic kidney disease

% Improved KW% Improved BUNModelDurationReference
Soy versus casein protein27.470aHan:SPRD, M3 to 10 wAukema; Kidney Int 59: 52, 2001
Enalapril, 50 mg/L po22.843.9aHan:SPRD, M3 to 16 wKeith; Am J Kidney Dis 24: 491, 1994
Enalapril, 50 mg/L po31.074.2aHan:SPRD, M3 to 10 wKennefick; Kidney Int 56: 2181, 1999
Enalapril, 50 mg/L po32.748.1bHan:SPRD, M3 to 40 wKennefick; Kidney Int 56: 2181, 1999
Losartan, 400 mg/L po12.363.4aHan:SPRD, M3 to 16 wKeith; Am J Kidney Dis 24: 491, 1994
Lovastatin, 4 mg/Kg per day ip21.758.8Han:SPRD, M4 to 10 wGile; Am J Kidney Dis 26: 501, 1995
Methylprednisolone, 1–2 mg/Kg per d po65.774.0pcy4 to 18 wGattone; Am J Kidney Dis 25: 302, 1995
Methylprednisolone, 1–2 mg/Kg per d po33.140.1Han:SPRD, M3 to 10 wGattone; Am J Kidney Dis 25: 302, 1995
WTACE2, 100 mg/kg per d ip46.754.8bpk7 to 21 dDell; Kidney Int 60: 1240, 2001
EKI-785, 90 mg/Kg q3d ip66.7100.0bpk7 to 24 dSweeney; Kidney Int 57: 33, 2000
EKI-785, 90 mg/Kg q3d ip85.5100.0bpk7 to 21 dSweeney; Kidney Int 64: 1310, 2003
EKI-785, 90 mg/Kg q3d ip21.241.8Han:SPRD, M3 to 10 wTorres; Kidney Int 64: 1573, 2003
EKB-569, 90 mg/Kg q3d ip75.294.8bpk7 to 21 dSweeney; Kidney Int 64: 1310, 2003
EKB-569, 30 mg/Kg q3d + WTACE2 100 mg/Kg altd ip74.394.8bpk7 to 21 dSweeney; Kidney Int 64: 1310, 2003
EKB-569, 20 mg/Kg q3d ip38.159.5Han:SPRD, M3 to 10 wTorres; Kidney Int 64: 1573, 2003
c-myc antisense oligomer, 30 mcg/d ip36.766.0cpk21 dRicker; Kidney Int 61: S125, 2002
Rapamycin, 0.2 mg/Kg per d ip64.684.6Han:SPRD, M3 to 8 wTao; J Am Soc Nephrol 16: 46, 2005
OPC-31260, 100–200 mcg per d sq54.486.4cpk3 to 21 dGattone; Develop Genet 24: 309, 1999
OPC-31260, 0.1% po86.262.2pcy4 to 30 wGattone; Nature Med 9: 1323, 2003
OPC-31260, 0.1% po75.095.9PCK3 to 10 wGattone; Nature Med 9: 1323, 2003
OPC-31260, 0.05% po98.499.5Pkd2-/WS253 to 16 wTorres; Nature Med 10: 363, 2004
  • a Data are based on serum creatinine values.

  • b Data are based on inulin clearance.