Table 2.

Changes in iron parameters, hemoglobin, fibroblast growth factor 23, and hepcidin after 12 weeks of ferric citrate versus ferrous sulfate

Baseline Values, Mean (SD)12-Wk Change from Baseline, Mean Estimate (95% CI)
VariableFerrous SulfateFerric CitrateFerrous SulfateFerric CitrateDifferenceP Value
Primary outcomes
 TSAT, %21 (7)19 (7)−1 (−3 to 2)8 (1 to 14)8 (1 to 15)0.02
 Ferritin, ng/ml104 (63)87 (61)12 (−4 to 28)49 (26 to 73)37 (10 to 64)0.009
Secondary outcomes
 Hemoglobin, g/dl11.0 (1.1)11.4 (1.1)0.0 (−0.3 to 0.4)0.3 (0.1 to 0.5)0.3 (−0.1 to 0.2)0.19
 iFGF23, pg/ml178 (102)160 (290)−7 (−22 to 8)−37 (−74 to 0)−29 (−59 to 0.1)0.05
 cFGF23, RU/ml437 (510)291 (353)−104 (−219 to 11)−45 (−92 to 1)61 (−58 to 181)0.31
 Hepcidin, pg/ml87 (48)82 (61)21 (−8 to 49)90 (30 to 150)69 (8 to 130)0.03
  • 95% CI, 95% confidence interval; TSAT, transferrin saturation; iFGF23, intact fibroblast growth factor 23; cFGF23, C-terminal fibroblast growth factor 23.