Table 2.

Age-dependent imaging-based criteria for diagnosis and exclusion of autosomal dominant polycystic kidney disease in the context of positive family history

AgeNo. of Cysts
Unified ultrasound criteriaa
 For confirmation of ADPKD
  15–39≥3: PPV 100%
  40–59≥2/kidney: PPV 100%
 For disease exclusion
  15–29None: NPV 91%
  30–39None: NPV 98%
  40–59<2: NPV 100%
MRI criteriab
 For confirmation of ADPKD
  16–40>10: PPV 100%
 For disease exclusion
  16–40<5: NPV 100%
  • ADPKD, autosomal dominant polycystic kidney disease; PPV, positive predictive value; NPV, negative predictive value; MRI, magnetic resonance imaging.

  • a Modified from ref. 43, with permission.

  • b Modified from ref. 44, with permission.