Table 1.

Baseline characteristics and selected outcomes of the hospitalized cohort stratified by baseline eGFR

Baseline eGFR of <30 ml/min per 1.73 m2 (n = 1546)Baseline eGFR of 30 to 59 ml/min per 1.73 m2 (n = 6560)Baseline eGFR of ≥60 ml/min per 1.73 m2 (n = 21,539)P
Age, years74.9 (13.7)77.6 (11.6)60.4 (19.2)<0.001
Female gender, n (%)878 (56.8)3807 (58.0)10749 (49.9)<0.001
Race, n (%)
    white1192 (77.1)5703 (86.9)17598 (81.7)<0.001
    black75 (4.9)186 (2.8)1090 (5.1)
    other279 (18.1)671(10.2)2851 (13.2)
Baseline sCr, mg/dl2.5 (2.0 to 3.4)1.3 (1.1 to 1.4)0.8 (0.7 to 0.9)<0.001
Baseline eGFR, ml/min per 1.73 m221.6 (15.1 to 26.4)48.5 (41.0 to 54.3)87.8 (74.1 to 105.4)<0.001
Hospital service, n (%)
    medical1429 (92.4)5727 (87.3)16928 (78.6)<0.001
    surgical70 (4.5)624 (9.5)3072 (14.3)
    other47 (3.0)209 (3.2)1539 (7.2)
Coexisting conditions, n (%)
    diabetes mellitus382 (24.7)1628 (24.8)3357 (15.6)<0.001
    myocardial infarction302 (19.5)1223 (18.6)2889 (13.4)<0.001
    congestive heart failure611 (39.5)1943 (29.6)2251 (10.5)<0.001
    peripheral vascular disease165 (10.7)460 (7.0)751 (3.5)<0.001
    cerebrovascular disease123 (8.0)559 (8.5)1166 (5.4)<0.001
    hemiplegia or paraplegia3 (0.2)17 (0.3)104 (0.5)0.02
    dementia35 (2.3)212 (3.2)296 (1.4)<0.001
    chronic obstructive pulmonary disease328 (21.2)1304 (19.9)3510 (16.3)<0.001
    rheumatologic disease30 (1.9)155 (2.4)358 (1.7)0.001
    peptic ulcer disease28 (1.8)132 (2.0)384 (1.8)0.49
    liver disease37 (2.4)86 (1.3)282 (1.3)0.002
    chronic kidney disease311 (20.1)373 (5.7)75 (0.4)<0.001
    any malignancy99 (6.4)489 (7.5)1497 (7.0)0.23
    AIDS3 (0.2)5 (0.1)67 (0.3)0.004
Deyo-Charlson comorbidity index, n (%)
    0255 (16.5)1704 (25.9)10064 (46.7)<0.001
    1373 (24.1)1899 (29.0)6205 (28.8)
    2353 (22.8)1515 (23.1)2975 (13.8)
    ≥3565 (36.6)1442 (22.0)2295 (10.7)
Acute hospital-related factors, n (%)
    sepsis24 (1.6)50 (0.8)119 (0.6)<0.001
    cardiac catheterization120 (7.8)720 (11.0)2672 (12.4)<0.001
    abdominal surgery26 (1.7)123 (1.9)629 (2.9)<0.001
    CABG30 (1.9)327 (4.9)1176 (5.5)<0.001
    AOSD score
        01331 (86.1)6071 (92.6)20442 (94.9)<0.001
        1 to 2202 (13.1)475 (7.2)1076 (5.0)
        ≥313 (0.8)14 (0.2)21 (0.1)
Selected hospital outcomes
    discharge to facility, n (%)a705 (53.2)2843 (46.2)6279 (29.8)<0.001
    hospital length of stay, daysa5 (3 to 9)4 (2 to 8)4 (2 to 6)<0.001
    in-hospital death, n (%)220 (14.2)406 (6.2)478 (2.2)<0.001
  • The data are presented as the means (SD), medians (25th to 75th percentile), or frequencies (percentages). sCr, serum creatinine; eGFR, estimated GFR; CABG, coronary artery bypass grafting; AOSD, acute organ system dysfunction.

  • a The discharge disposition and hospital length of stay refer only to patients who were discharged alive.