Table 5.

Diagnostic accuracy (area under the ROC curves, sensitivity, and specificity) of cystatin C estimated GFR estimated by various cystatin C equations across different GFR categories (ml/min per 1.73 m2)

Area under the ROC Curve (AUC) (95% CI)SEMSensitivity (%)Specificity (%)
GFR<60 ml/min per 1.73 m2
    equations with serum cystatin C
        Bökenkamp et al.0.99 (0.96 to 0.99)0.00583.87 (66.3 to 94.5)100.00 (98.3 to 100.0)
        Filler and Lepage0.99 (0.96 to 0.99)0.00583.87 (66.3 to 94.5)100.00 (98.3 to 100.0)
        Grubb et al.0.98 (0.95 to 0.99)0.00880.65 (62.5 to 92.5)98.09 (95.2 to 99.5)
        Zapitelli-CysEq0.99 (0.97 to 0.99)0.00496.77 (83.3 to 99.9)94.74 (90.8 to 97.3)
    equations with serum cystatin C and serum creatinine
        Bouvet et al.1.00 (0.98 to 1.00)0.00064.52 (45.4 to 80.8)100.00 (98.3 to 100.0)
        CKiD0.98 (0.95 to 0.99)0.01390.32 (74.2 to 98.0)97.13 (93.9 to 98.9)
        Zapitelli-CysCrEq0.98 (0.96 to 0.99)0.00893.55 (78.6 to 99.2)90.43 (85.6 to 94.1)
GFR<90 ml/min per 1.73 m2
    equations with serum cystatin C
        Bökenkamp et al.0.97 (0.94 to 0.99)0.01160.81 (48.8 to 72.0)100.00 (97.8 to 100.0)
        Filler and Lepage0.97 (0.94 to 0.99)0.01189.19 (79.8 to 95.2)95.78 (91.5 to 98.3)
        Grubb et al.0.97 (0.93 to 0.98)0.01078.38 (67.3 to 87.1)98.19 (94.8 to 99.6)
        Zapitelli-CysEq0.97 (0.94 to 0.98)0.01298.65 (92.7 to 100.0)81.33 (74.6 to 86.9)
    equations with serum cystatin C and serum creatinine
        Bouvet et al.1.00 (0.98 to 1.00)0.00086.49 (76.5 to 93.3)100.00 (97.8 to 100.0)
        CKiD0.97 (0.94 to 0.99)0.007100.00 (95.1 to 100)77.11 (70.0 to 83.3)
        Zapitelli-CysCrEq0.98 (0.95 to 0.99)0.00698.65 (92.7 to 100.0)79.52 (72.6 to 85.4)
GFR ≥ 135 ml/min per 1.73 m2
    equations with serum cystatin C
        Bökenkamp et al.0.85 (0.80 to 0.89)0.02397.47 (91.2 to 99.7)60.87 (52.9 to 68.5)
        Filler and Lepage0.85 (0.80 to 0.89)0.02348.10 (36.7 to 59.6)86.34 (80.0 to 91.2)
        Grubb et al.0.83 (0.78 to 0.88)0.02588.61 (79.5 to 94.7)63.35 (55.4 to 70.8)
        Zapitelli-CysEq0.83 (0.78 to 0.88)0.02517.72 (10.0 to 27.9)95.65 (91.2 to 98.2)
    equations with serum cystatin C and serum creatinine
        Bouvet et al.1.00 (0.98 to 1.00)0.00058.02 (46.5 to 68.9)100.00 (97.7 to 100.0)
        CKiD0.84 (0.79 to 0.89)0.02412.66 (6.2 to 22.0)96.89 (92.9 to 99.0)
        Zapitelli-CysCrEq0.85 (0.80 to 0.89)0.02320.25 (12.0 to 30.8)96.27 (92.1 to 98.6)
GFR ≥ 150 ml/min per 1.73 m2
    equations with serum cystatin C
        Bökenkamp et al.0.84 (0.79 to 0.89)0.02597.37 (86.2 to 99.9)65.84 (58.9 to 72.4)
        Filler and Lepage0.84 (0.79 to 0.89)0.02539.47 (24.0 to 56.6)91.58 (86.9 to 95.0)
        Grubb et al.0.84 (0.78 to 0.88)0.02689.47 (75.2 to 97.1)59.90 (52.8 to 66.7)
        Zapitelli-CysEq0.83(0.78 to 0.88)0.02613.16 (4.4 to 28.1)98.02 (95.0 to 99.5)
    equations with serum cystatin C and serum creatinine
        Bouvet et al.1.00 (0.98 to 1.00)0.00051.22 (35.1 to 67.1)100.00 (98.2 to 100.0)
        CKiD0.84 (0.79 to 0.88)0.0287.89 (1.7 to 21.4)99.50 (97.3 to 100.0)
        Zapitelli-CysCrEq0.85(0.80 to 0.89)0.02615.79 (6.0 to 31.3)98.51 (95.7 to 99.7)
  • ROC, receiver operating characteristic; AUC, area under curve; CI, confidence interval; CKiD, chronic kidney disease in children. P < 0.001 for all AUC estimations.