Table 2.

Logistic regression analyses examining the association of nadir-to-peak serum creatinine (sCr) increments and in-hospital mortality stratified by baseline eGFR

SubjectsDeaths (%)Adjusted Odds Ratio (95% Confidence Interval)
Baseline eGFR of ≥60 ml/min per 1.73 m2
    total21,539478
    nadir-to-peak sCr increment (mg/dl)
        013,851131 (0.9)1.0
        0.13,44343 (1.3)1.16 (0.82 to 1.64)
        0.21,91733 (1.8)1.67 (1.13 to 2.47)
        0.31,15638 (3.3)1.97 (1.31 to 2.95)
        0.429326 (9.2)5.11 (3.14 to 8.32)
        0.524829 (10.1)6.37 (3.89 to 10.43)
        >0.5631155 (28.5)16.71 (12.54 to 22.28)
Baseline eGFR of 30 to 59 ml/min per 1.73 m2
    total6,560406
    nadir-to-peak sCr increment (mg/dl)
        03,46894 (2.7)1.0
        0.11,24135 (2.8)0.97 (0.65 to 1.45)
        0.231415 (4.8)1.53 (0.87 to 2.72)
        0.351643 (8.3)2.69 (1.82 to 3.97)
        0.41198 (6.7)2.02 (0.91 to 4.46)
        0.520529 (14.1)4.69 (2.91 to 7.57)
        >0.5697182 (26.1)9.09 (6.75 to 12.24)
Baseline eGFR of <30 ml/min per 1.73 m2
    total1,546220
    nadir-to-peak sCr increment (mg/dl)
        067059 (8.8)1.0
        0.113813 (9.4)0.76 (0.36 to 1.53)
        0.210910 (9.2)1.03 (0.49 to 2.12)
        0.38213 (15.9)1.68 (0.82 to 3.44)
        0.4a350 (0.0)
        0.56512 (18.5)2.15 (1.02 to 4.51)
        >0.5447113 (25.3)2.65 (1.79 to 3.93)
  • The model is adjusted for age, gender, race, Deyo-Charlson comorbidity index, hospital service, sepsis, cardiac catheterization, coronary artery bypass grafting, abdominal surgery, and acute organ system dysfunction score. eGFR, estimated GFR.

  • a The odds ratio could not be calculated because there were no deaths in this group.