Table 3.

Kidney biopsy findings

CharacteristicsNumber
No. of glomeruli, n=2316 (range, 6–30)
Obsolescent glomeruli, %, n=2311 (range, 0–50)
FSGS lesions, %, n=21/2364 (range, 12.5–100)
Collapsing lesions, %, n=18/2150 (range, 4–100)
Interstitial fibrosis, %, n=2318 (range, 0–50)
Interstitial infiltrate, n=2318 (78%)
Interstitial edema, n=237 (30%)
Tubular microcyst dilation, n=2315 (65%)
Acute tubular necrosis, n=2315 (65%)
Arteriolar hyalinosis, n=23a15 (65%)
Definitive pathologic diagnosis
 FSGSb21 (91%)
  Collapsing glomerulopathy18
  Including HIV-associated nephropathy9
  Not otherwise specified variant3
 Minimal change disease2 (9%)
  • a Arteriolar hyalinosis was scored as follows: +, mild; ++, moderate; +++, severe.

  • b In one patient with HIV infection, kidney biopsy findings were consistent with not otherwise specified variant. In one patient, HIV-associated nephropathy lesions were associated with additional membranoproliferative GN lesions. In one patient, HIV-associated nephropathy lesions were associated with thrombotic microangiopathy lesions.