Table 1.

Baseline characteristics of German CKD study participants, stratified by quartiles of serum uromodulin (n=5143)

CharacteristicsTotal Cohort (n=5143)Quartile 1 (n=1286)Quartile 2 (n=1287)Quartile 3 (n=1285)Quartile 4 (n=1285)Missing Data (n [%])
Serum uromodulin range (ng/ml)0.0–490.4≤55.6>55.6–83.4>83.4–125.3>125.3
Demographics
 Age (yr)60±1261±1261±1160±1258±131 (0)
 Male3088 (60)833 (65)824 (64)766 (60)665 (52)0 (0)
Laboratory measures
 eGFR<60 ml/min per 1.73 m24007 (78)1185 (92)1116 (87)984 (77)722 (56)28 (0.5)
 eGFR (ml/min per 1.73 m2)49±1840±1345±1451±1762±2028 (0.5)
 Albuminuria (ACR>30 mg/g Cr)2987 (58)867 (67)793 (62)720 (56)607 (47)83 (2)
 ACR (mg/g Cr)51 (10–389)89 (15–603)61 (13–426)43 (9–350)24 (7–250)83 (2)
 Hemoglobin (g/dl)13.6±1.713.1±1.713.5±1.713.8±1.614.0±1.596 (2)
 CRP (mg/dl)2.3 (1.0–5.0)3.0 (1.3–6.6)2.5 (1–5.5)2.2 (1–4.9)1.7 (0.8–3.5)27 (0.5)
 HbA1c (%)6.2±1.06.5±1.26.4±1.06.4±1.06.1±0.837 (0.7)
 Total cholesterol (mg/dl)211±53206±54207±53214±50218±5233 (0.6)
 LDL cholesterol (mg/dl)118±43112±44115±44121±42125±4438 (0.7)
 HDL cholesterol (mg/dl)52±1848±1750±1753±1857±1937 (0.7)
 Triglycerides (mg/dl)113 (89–143)182 (126–268)177 (123–247)161 (115–233)155 (105–212)38 (0.7)
 Phosphate (mg/dl)3.4±0.63.5±0.73.4±0.63.4±0.63.4±0.626 (0.5)
 Uric acid (mg/dl)7.2±1.97.8±2.17.4±1.97.2±1.76.4±1.726 (0.5)
Cardiovascular risk factors and prevalent cardiovascular disease
 Systolic BP (mm Hg)140±20140±21141±21140±20138±2032 (0.6)
 Diastolic BP (mm Hg)79±1278±1380±1280±1280±1132 (0.6)
 BMI (kg/m2)29.8±6.031.0±6.530.1±5.929.7±5.828.4±5.353 (1)
 Diabetes1830 (36)575 (45)490 (38)465 (36)300 (23)0 (0)
 Hypertension4952 (96)1268 (99)1271 (99)1239 (96)1174 (91)3 (0.1)
 Coronary heart disease1022 (20)310 (24)284 (22)258 (20)170 (13)2 (0)
 Stroke497 (10)151 (12)143 (11)118 (9)85 (7)2 (0)
 Smoking history15 (0.3)
  Never2101 (41)467 (36)494 (38)546 (43)594 (46)
  Former2213 (43)585 (46)573 (45)537 (42)518 (40)
  Current815 (16)228 (18)217 (17)199 (16)171 (13)
  Unknown14 (0)6 (0)3 (0)3 (0)2 (0)
Medication use
 ACE inhibitor2434 (47)639 (50)609 (47)624 (49)562 (44)0 (0)
 Angiotensin-II receptor blocker2142 (42)583 (45)563 (44)533 (42)463 (36)0 (0)
 Diuretic3133 (61)976 (76)870 (68)744 (58)543 (42)0 (0)
 Lipid-lowering therapy2624 (51)734 (57)709 (55)632 (49)549 (43)0 (0)
β-Blocker2822 (55)828 (64)773 (60)678 (53)543 (42)0 (0)
 Calcium-channel blocker2036 (40)605 (47)565 (44)488 (38)378 (29)0 (0)
Lifestyle factors
 Drinking31 (0.6)
  Light4142 (81)1003 (78)1036 (81)1062 (83)1041 (81)
  Heavy971 (19)272 (21)244 (19)217 (17)238 (19)
  Unknown30 (0)11 (0)7 (0)6 (0)6 (0)
Underlying kidney disease0 (0)
 Diabetes1382 (27)454 (35)376 (29)341 (27)211 (16)
 Hypertension2121 (41)576 (45)558 (43)528 (41)459 (36)
 Systemic disease606 (12)140 (11)142 (11)164 (13)160 (13)
 GN1171 (23)288 (22)278 (22)274 (21)331 (26)
 Interstitial nephropathy437 (9)94 (7)111 (9)115 (9)117 (9)
 Hereditary232 (5)59 (5)58 (5)72 (6)43 (3)
 Obstructive374 (7)79 (6)103 (8)88 (7)104 (8)
 AKI242 (5)75 (6)65 (5)62 (5)40 (3)
 Solitary kidney324 (8)92 (7)69 (5)76 (6)87 (7)
 Miscellaneous236 (5)74 (6)53 (4)42 (3)67 (5)
 Undetermined319 (6)71 (6)72 (6)82 (6)94 (7)
  • Continuous variables are presented as mean and SD or median and interquartile range, and categoric variables are presented in percentage of referring population, unless otherwise specified. ACR, albumin-creatinine ratio; CRP, C-reactive protein; HbA1c, hemoglobin A1c; BMI, body mass index; ACE, angiotensin-converting enzyme.