Table 3.

eGFR slopes before and after discontinuation or renin-angiotensin-aldosterone system inhibitors

PopulationNeGFR Slope before DiscontinuationeGFR Slope after DiscontinuationP Value
Total study population69−1.5 (−2.4 to −0.6)−3.9 (−5.1 to −2.6)0.005
Study population with known reason of discontinuation61−1.6 (−2.5 to −0.7)−4.0 (−5.2 to −2.7)0.006
Reasons of discontinuation
 Increase in serum creatinine23−2.3 (−3.0 to −1.5)−3.6 (−5.2 to −2.0)0.18
 Hyperkalemia16−1.3 (−2.5 to −0.0)−3.8 (−6.4 to −1.2)0.12
 Symptomatic hypotension12−1.5 (−4.9 to 1.8)−6.8 (−11.9 to −1.8)0.11
  • Data are mean (95% confidence interval) eGFR slope (ml/min per 1.73 m2 per yr).