Table 2.

Associations of continuous eGFR with individual gait variables

Gait VariableeGFR≥60, per 10-ml/min per 1.73 m2 Lower eGFR, n=196eGFR<60, per 10-ml/min per 1.73 m2 Lower eGFR, n=134Age, per 5-yr Older Age, n=330
Coefficient (95% CI)P ValueCoefficient (95% CI)P ValueCoefficient (95% CI)P Value
Walking while talking
 Speed, cm/s0.01 (−2.7 to 2.7)0.99−3.3 (−6.1 to −0.4)0.03−6.1 (−8.2 to −4.0)<0.001
 Cadence, steps per 1 min−0.7 (−3.0 to 1.7)0.57−1.0 (−3.5 to 1.5)0.43−1.7 (−3.5 to 0.2)0.07
 Step length, cm0.6 (−0.6 to 1.7)0.35−1.8 (−3.0 to −0.6)0.005−3.5 (−4.4 to −2.6)<0.001
 Swing, %0.5 (0.01 to 1.1)0.05−1.1 (−1.7 to −0.6)<0.001−0.9 (−1.3 to −0.5)<0.001
 Stance, %−0.5 (−1.1 to −0.01)0.051.1 (0.6 to 1.7)<0.0010.9 (0.5 to 1.3)<0.001
 Double support, %−0.4 (−1.2 to 0.5)0.381.4 (0.5 to 2.3)0.0031.8 (1.2 to 2.5)<0.001
 Step time SD, s0.02 (−0.01 to 0.05)0.20−0.01 (−0.04 to 0.03)0.770.01 (−0.01 to 0.03)0.39
 Swing time SD, s0.01 (−0.01 to 0.02)0.36−0.01 (−0.02 to 0.01)0.500.01 (−0.00 to 0.02)0.29
DTC
 Speed DTC, %0.4 (−2.0 to 2.7)0.76−1.3 (−3.8 to 1.2)0.30−1.2 (−3.0 to 0.6)0.18
 Cadence DTC, %−0.2 (−2.3 to 1.9)0.87−0.9 (−3.1 to 1.3)0.41−0.5 (−2.1 to 1.1)0.53
 Step length DTC, %0.5 (−0.9 to 1.9)0.46−0.6 (−2.0 to 0.9)0.42−1.3 (−2.3 to −0.2)0.02
 Swing DTC, %1.3 (0.03 to 2.6)0.04−1.8 (−3.2 to −0.5)0.01−0.9 (−1.9 to 0.1)0.09
 Stance DTC, %−0.6 (−1.2 to 0.01)0.050.9 (0.2 to 1.5)0.010.3 (−0.2 to 0.7)0.29
 Double-support DTC, %−0.9 (−2.5 to 0.7)0.261.5 (−0.2 to 3.2)0.091.1 (−0.2 to 2.3)0.10
 Step time SD DTC, % (n=327)144.4 (−69.8 to 358.6)0.19−62.0 (−288.5 to 164.4)0.5917.9 (−145.9 to 181.7)0.83
 Swing time SD DTC, % (n=329)58.2 (−16.0 to 132.5)0.12−34.3 (−113.2 to 44.6)0.39−7.9 (−65.0 to 49.2)0.79
  • Multivariable linear regression adjusting for age, sex, race, education, body mass index, neuropathy, number of comorbidities, and number of medications was performed. Linear splines for eGFR were constructed with knot placed at 60 ml/min per 1.73 m2. DTC = (walking while talking dual-task gait variable – walking-only single-task gait variable)/(walking-only single-task gait variable) ×100%. 95% CI, 95% confidence interval; DTC, dual-task cost.