Table 2.

Cox regression analyses of the main effect of ADMA, CRP, and IL-6 on the incidence rate of mortality and fatal and nonfatal CV events

Variables (units of increase)Hazard Ratio (95% CI) and P Value
ADMA and CRP-based ModelADMA and IL-6-based Model
All-cause mortality
    age (1 year)1.04 (1.02 to 1.06), P < 0.0011.04 (1.02 to 1.05), P < 0.001
    male gender1.67 (1.07 to 2.61), P = 0.021.55 (0.99 to 2.41), P = 0.06
    smoking1.22 (0.80 to 1.86), P = 0.361.24 (0.81 to 1.89), P = 0.32
    diabetes2.26 (1.45 to 3.51), P < 0.0012.42 (1.55 to 3.78), P < 0.001
    cholesterol (20 mg/dl)1.01 (0.94 to 1.08), P = 0.811.02 (0.95 to 1.09), P = 0.64
    systolic pressure (1 mmHg)1.00 (0.99 to 1.01), P = 0.0061.00 (0.99 to 1.01), P = 0.94
    CV comorbidities (0 = no; 1 = yes)1.65 (1.16 to 2.36), P = 0.0061.57 (1.10 to 2.23), P = 0.01
    anti-hypertensive treatment (0 = no; 1 = yes)0.89 (0.60 to 1.31), P = 0.560.87 (0.59 to 1.29), P = 0.50
    dialysis vintage (10 months)1.00 (0.98 to 1.03), P = 0.981.00 (0.97 to 1.02), P = 0.87
    albumin (1 g/L)0.97 (0.93 to 1.01), P = 0.140.98 (0.94 to 1.02), P = 0.27
    hemoglobin (1 g/L)1.01 (0.99 to 1.02), P = 0.081.01 (0.99 to 1.02), P = 0.11
    calcium phosphate (1 mmol2/L2)1.04 (0.89 to 1.21), P = 0.661.06 (0.91 to 1.24), P = 0.47
    homocysteine (10 μmol/L)1.04 (0.98 to 1.10), P = 0.211.03 (0.98 to 1.09), P = 0.22
    ADMA (1 μmol/L)1.22 (1.12 to 1.34), P < 0.0011.21 (1.10 to 1.32), P < 0.001
    CRP (5 mg/L)1.04 (1.01 to 1.07), P = 0.008
    IL-6 (1 pg/ml)1.03 (1.01 to 1.05), P = 0.002
Fatal and nonfatal CV events
    age (1 year)1.03 (1.02 to 1.06), P < 0.0011.03 (1.02 to 1.06), P < 0.001
    male gender1.36 (0.82 to 2.27), P = 0.231.34 (0.80 to 2.24), P = 0.27
    smoking1.59 (0.99 to 2.56), P = 0.061.61 (1.00 to 2.58), P = 0.05
    diabetes1.92 (1.16 to 3.18), P = 0.011.94 (1.17 to 3.23), P = 0.01
    cholesterol (20 mg/dl)1.04 (0.96 to 1.12), P = 0.321.04 (0.96 to 1.12), P = 0.31
    systolic pressure (1 mmHg)1.01 (0.99 to 1.02), P = 0.861.00 (0.99 to 2.58), P = 0.87
    CV comorbidities (0 = no; 1 = yes)1.56 (1.03 to 2.35), P = 0.041.55 (1.02 to 2.34), P = 0.04
    anti-hypertensive treatment (0 = no; 1 = yes)2.02 (1.31 to 3.12), P = 0.0022.00 (1.29 to 3.09), P = 0.002
    dialysis vintage (10 months)1.03 (0.99 to 1.06), P = 0.061.03 (0.99 to 1.06), P = 0.06
    albumin (1 g/L)0.98 (0.94 to 1.03), P = 0.480.98 (0.94 to 1.03), P = 0.52
    hemoglobin (1 g/L)1.01 (0.99 to 1.02), P = 0.281.01 (0.99 to 1.02), P = 0.30
    calcium phosphate (1 mmol2/L2)1.05 (0.88 to 1.25), P = 0.601.05 (0.89 to 1.25), P = 0.56
    homocysteine (10 μmol/L)1.02 (0.96 to 1.09), P = 0.511.02 (0.96 to 1.09), P = 0.52
    ADMA (1 μmol/L)1.18 (1.07 to 1.30), P = 0.0011.17 (1.06 to 1.29), P = 0.001
    CRP (1 mg/L)1.01 (0.97 to 1.06), P = 0.61
    IL-6 (1 pg/ml)1.01 (0.98 to 1.03), P = 0.60
  • CRP, C-reactive protein; CV, cardiovascular; ADMA, asymmetric dimethylarginine; CI, confidence interval.