Table 4.

Association between systolic BP parameters and ESKD in unadjusted and adjusted analyses along with model discrimination

Systolic BP Metrics (n=533)Unadjusted HR (95% CI)aUnadjusted c-Statistic (95% CI)Adjusted HR (95% CI)a,bAdjusted c-Statistic (95% CI)b
Awake systolic BP load (every 10% higher)1.2 (1.1 to 1.2)0.60 (0.54 to 0.65)c1.1 (1.0 to 1.1)0.89 (0.86 to 0.91)c
Awake systolic BP index (every 0.1 higher)1.6 (1.3 to 1.9)0.60 (0.55 to 0.65)1.2 (1.0 to 1.5)0.89 (0.86 to 0.91)
Awake systolic BP load plus awake systolic BP index1.1 (1.0 to 1.3)
1.2 (0.7 to 1.9)
0.60 (0.55 to 0.67)0.9 (0.7 to 1.0)
1.8 (1.1 to 3.2)
0.89 (0.85 to 0.91)
Asleep systolic BP load (every 10% higher)1.1 (1.0 to 1.2)0.58 (0.52 to 0.64)c1.0 (1.0 to 1.0)0.88 (0.85 to 0.91)c
Asleep systolic BP index (every 0.1 higher)1.4 (1.1 to 1.6)0.57 (0.52 to 0.63)1.2 (1.0 to 1.4)0.89 (0.85 to 0.91)
Asleep systolic BP load plus asleep systolic BP index1.1 (0.9 to 1.2)
1.1(0.7 to 1.7)
0.58 (0.52 to 0.64)1.0 (0.8 to 1.1)
1.3 (0.9 to 2.1)
0.88 (0.85 to 0.91)
  • HR, hazard ratio.

  • a HR reported for every 0.1 higher in systolic BP index or 10% higher systolic BP load.

  • b Adjusted for age, sex, race, cause of CKD, body mass index z-score, duration of CKD, urine protein-creatinine ratio, serum albumin, hemoglobin, antihypertensive use, and baseline eGFR (by bedside Schwartz), n=515 included due to missing covariates.

  • c Reference group for awake or asleep c-statistic comparisons.