Table 10.

Comparative efficacy of currently available statins on lipids and lipoproteins

Mean Change in Lipid and Lipoprotein Levels
Rosuvastatin (Crestor®)Atorvastatin (Lipitor®)Simvastatin (Zocor®)Lovastatin (Mevacor®)Pravastatin (Pravacol®)Fluvastatin (Lescol®)TotalLDLHDLTriglycerides
0.512448
5 mg10 mg10 mg20 mg−17%−21%NR−5 to −10%
5 mg10 mg20 mg20 mg40 mg−22%−27%+4 to 8%−10 to −15%
5 mg10 mg20 mg40 mg40 mg80 mg−27%−34%+4 to 8%−10 to −20%
10 mg20 mg40 mg80 mg−32%−41%+4 to 8%−15 to −25%
20 mg40 mg80 mg−37%−48%+4 to 8%−20 to −30%
40 mg80 mg−42%−55%+4 to 8%−25 to −35%
  • Relative potency of individual agents (in decreasing order with smaller numbers reflecting the higher potency agent), doubling the dose increases efficacy by 8 to 10%.