Table 2.

Effect of the sodium bicarbonate intervention on acid-base indices

MeasurementSerum Total CO2 (meq/L)Urinary NH4+ (meq/d)Urinary TA (meq/d)Urinary pH
Sodium BicarbonatePlaceboSodium BicarbonatePlaceboSodium BicarbonatePlaceboSodium BicarbonatePlacebo
Within-group Δ from baseline
 At mo 31.3 (0.4 to 2.1)0.1 (−0.8 to 0.9)−8 (−13 to −3)−1 (−5 to 4)−10 (−15 to −5)2 (−3 to 7)0.6 (0.5 to 0.8)0.0 (−0.2 to 0.1)
 At mo 61.0 (0.3 to 1.8)−0.2 (−0.9 to 0.6)−5 (−11 to 1)−1 (−7 to 5)−11 (−16 to −5)0 (−5 to 6)0.7 (0.6 to 0.9)0.1 (−0.1 to 0.3)
 Over mo 3 and 61.2 (0.5 to 1.9)0.0 (−0.7 to 0.7)−6 (−11 to −2)−1 (−6 to 3)−10 (−15 to −6)1 (−4 to 6)0.7 (0.5 to 0.8)0.0 (−0.1 to 0.2)
Sodium Bicarbonate versus PlaceboSodium Bicarbonate versus PlaceboSodium Bicarbonate versus PlaceboSodium Bicarbonate versus Placebo
Difference in change from baseline
 At mo 31.2 (0.0 to 2.4)−7 (−13 to −1)−12 (−19 to −5)0.7 (0.5 to 0.8)
 At mo 61.2 (0.1 to 2.2)−4 (−12 to 4)−11 (−19 to −3)0.6 (0.4 to 0.8)
 Over mo 3 and 61.2 (0.3 to 2.1)−5 (−11 to 0)−11 (−18 to −5)0.6 (0.5 to 0.8)
  • Data are shown as mean (95% confidence intervals). Positive values for difference in change indicate that the change was greater in the sodium bicarbonate group. TA, titratable acid.