Table 4.

Effects of the sodium bicarbonate intervention on exploratory outcomes (kidney function) and BP, total body weight, and serum potassium

VariableDifference in Change from Baseline to mo 3 (95% CI)Difference in Change from Baseline to mo 6 (95% CI)Difference in Change from Baseline to mo 3 and 6 (95% CI)
eGFR, ml/min per 1.73 m22.8 (−1.2 to 6.8)4.0 (−0.5 to 8.5)3.4 (−0.1 to 6.8)
BUN, mg/dl−6 (−9 to −2)−6 (−10 to −1)−6 (−9 to −2)
Creatinine clearance, ml/min0 (−11 to 11)5 (−9 to 20)3 (−8 to 13)
24-h urinary creatinine, mg/d−103 (−381 to 175)−6 (−320 to 308)−55 (−290 to 180)
Systolic BP, mm Hg6 (0 to 13)2 (−5 to 9)4 (−2 to 10)
Diastolic BP, mm Hg2 (−2 to 7)−1 (−4 to 4)1 (−2 to 5)
Total body wt, kg−1.3 (−3.0 to 0.5)−0.9 (−3.0 to 1.2)−1.1 (−2.8 to 0.6)
Serum potassium, meq/L−0.1 (−0.2 to 0.1)−0.1 (−0.3 to 0.1)−0.1 (−0.2 to 0.1)
  • Positive values for difference in change indicate that the change was greater in the sodium bicarbonate group. 95% CI, 95% confidence interval.