Table 1.

Types of hematopoietic stem cell transplant

Source of stem or progenitor cells
 Bone marrow
 Peripheral blood
 Umbilical cord blood
Type of donor
 Autologous (patient)
 Allogeneic (relative [usually a nonidentical sibling] or unrelated donor; requires prophylaxis against GVHD, often in the form of a CNI)
 Syngeneic (identical twin)
Type of conditioning regimen
 Myeloablative (most toxic; aims to eradicate the bone marrow and underlying cancer)
 Nonmyeloablative (least toxic; aims to provide sufficient immunosuppression to permit engraftment of transplanted cells, which target tumor cells [graft versus tumor effect])
 Reduced-intensity conditioning (intermediate intensity)
  • GVHD, graft versus host disease; CNI, denotes calcineurin inhibitor.