Table 9.

Common inhibitors of the P450 CYP3A4 and CYP2C9 enzyme systems

CYP3A4 InhibitorsCYP2C9 Inhibitors
AmiodaroneFluvoxamineNelfinavirAmiodarone
CannabinoidsGrapefruit juiceNorfloxacinAzole antifungals
ClarithromycinIndinavirPropoxypheneChloramphenicol
CyclosporinItraconazoleQuinineCimetidine
DanazolKetoconazoleRitonavirFluoxetine
DelevirdineOmeprazoleSaquinavirFluvastatin
DiltiazemMetronidazoleSertralineFluvoxamine
ErythromycinMibefradilTroleandomycinMetronidazole
FluconazoleMiconazoleVerapamilOmeprazole
FluoxetineNefazodoneZafirlukastRitonavir
Sulaphenazole
TMP/SMX
  • TMP/SMX, Trimethoprim/Sulfamethoxazole.