Table 4.

Association between usual lipid values and the risk of atherosclerotic vascular events, nonatherosclerotic vascular events and nonvascular events, overall and by level of albuminuria

LipidAtherosclerotic Vascular EventsNonatherosclerotic Vascular EventsNonvascular Events
No. of EventsHR (95% CI)P ValueaNo. of EventsHR (95% CI)P ValueaNo. of EventsHR (95% CI)P Valuea
Triglycerides, per 1.5 times higher usual level0.810.660.32
 uACR≤300 mg/g3791.10 (0.98 to 1.23)3390.87 (0.77 to 0.99)21320.99 (0.94 to 1.04)
 uACR>300 mg/g3441.08 (0.96 to 1.21)3590.84 (0.75 to 0.94)18870.95 (0.91 to 1.00)
 All participants not on dialysis7871.09 (1.01 to 1.18)7630.87 (0.80 to 0.94)43420.98 (0.94 to 1.01)
HDL cholesterol, per 11 mg/dl higher usual level0.020.810.03
 uACR≤300 mg/g3790.78 (0.68 to 0.89)3391.06 (0.93 to 1.20)21320.95 (0.91 to 1.00)
 uACR>300 mg/g3440.95 (0.84 to 1.08)3591.08 (0.96 to 1.21)18871.03 (0.98 to 1.09)
 All participants not on dialysis7870.87 (0.80 to 0.96)7631.08 (1.00 to 1.18)43411.00 (0.97 to 1.04)
LDL cholesterol, per 22 mg/dl higher usual level0.710.060.11
 uACR≤300 mg/g3791.15 (1.00 to 1.32)3390.88 (0.75 to 1.02)21320.94 (0.89 to 1.00)
 uACR>300 mg/g3441.19 (1.04 to 1.36)3591.06 (0.93 to 1.21)18871.01 (0.95 to 1.07)
 All participants not on dialysis7871.19 (1.09 to 1.31)7630.96 (0.87 to 1.06)43420.98 (0.94 to 1.02)
Non-HDL cholesterol, per 28 mg/dl higher usual level0.640.050.05
 uACR≤300 mg/g3791.18 (1.04 to 1.33)3390.85 (0.74 to 0.98)21320.94 (0.89 to 0.99)
 uACR>300 mg/g3441.23 (1.09 to 1.38)3591.01 (0.90 to 1.14)18871.01 (0.96 to 1.07)
 All participants not on dialysis7871.22 (1.12 to 1.32)7630.94 (0.86 to 1.03)43410.99 (0.95 to 1.03)
Apo-B, per 17 mg/dl higher usual level0.870.020.05
 uACR≤300 mg/g3791.19 (1.05 to 1.35)3390.86 (0.75 to 0.99)21320.96 (0.91 to 1.01)
 uACR>300 mg/g3441.21 (1.07 to 1.36)3591.07 (0.95 to 1.20)18861.04 (0.98 to 1.09)
 All participants not on dialysis7871.22 (1.12 to 1.33)7630.98 (0.89 to 1.07)43421.01 (0.97 to 1.05)
TRL cholesterol, per 14 mg/dl higher usual level0.780.280.14
 uACR≤300 mg/g3791.20 (1.03 to 1.40)3390.81 (0.66 to 0.99)21320.95 (0.87 to 1.02)
 uACR>300 mg/g3441.24 (1.08 to 1.42)3590.93 (0.79 to 1.09)18871.02 (0.95 to 1.10)
 All participants not on dialysis7871.22 (1.10 to 1.35)7630.90 (0.80 to 1.02)43411.01 (0.96 to 1.06)
TG/HDLc ratio, per 1.9 times higher usual level0.250.530.09
 uACR≤300 mg/g3791.20 (1.06 to 1.37)3390.88 (0.77 to 1.02)21321.02 (0.96 to 1.07)
 uACR>300 mg/g3441.08 (0.95 to 1.23)3590.83 (0.73 to 0.95)18870.95 (0.90 to 1.01)
 All participants not on dialysis7871.14 (1.04 to 1.25)7630.86 (0.79 to 0.95)43410.98 (0.94 to 1.02)
  • HRs adjusted for age, sex, ethnicity, treatment allocation, prior diabetes, prior vascular disease, smoking, body mass index, eGFR, and albuminuria. Average HR (95% CI) throughout the range of values studied (i.e., assuming a log-log-linear relationship for triglycerides and TG/HDLc ratio, and log-linear relationships for all other lipids), corresponding to about 1 SD differences in usual lipid values. HR, hazard ratio; 95% CI, 95% confidence interval; uACR, urinary albumin-to-creatinine ratio; TRL, triglyceride-rich lipoprotein; TRL cholesterol, total cholesterol minus LDL cholesterol minus HDL cholesterol; TG/HDLc, triglyceride to HDL cholesterol ratio.

  • a Test for effect modification by level of albuminuria.