Table 2.

Death and hospitalization events by category of time-varying eGFR and medication status

Time-varying eGFReGFR ≥90 ml/min per 1.73 m2eGFR ≥60 to <90 ml/min per 1.73 m2eGFR ≥30 to <60 ml/min per 1.73 m2eGFR <30 ml/min per 1.73 m2
Death
 NSAID use: events931277111
 NSAID use: incident rates4.6 (3.8–5.7)9.2 (7.7–10.9)27.7 (22.0–35.0)93.8 (52.0–169.4)
 Opiate use (<60 MMEs): events17530319545
 Opiate use (<60 MMEs): incident rates8.2 (7.1–9.5)19.2 (17.2–21.5)46.7 (40.6–53.7)156.3 (116.7–209.3)
 Opiate use (≥60 MMEs): events8214910239
 Opiate use (≥60 MMEs): incident rates9.8 (7.9–12.2)26.1 (22.2–30.6)106.7 (87.9–129.6)388.4 (283.8–531.7)
Incident hospitalization
 NSAID use: events74562818418
 NSAID use: incident rates48.4 (45.0–52.0)57.3 (53.0–62.0)100.7 (87.1–116.3)400.4 (252.3–635.5)
 Opiate use (<60 MMEs): events114685133038
 Opiate use (<60 MMEs): incident rates65.8 (62.1–69.7)71.0 (66.4–76.0)115.3 (103.5–128.4)266.8 (194.1–366.7)
 Opiate use (≥60 MMEs): events4513359315
 Opiate use (≥60 MMEs): incident rates73.4 (66.9–80.5)87.2 (78.4–97.1)158.7 (129.5–194.5)390.1 (235.2–647.1)
  • Ranges in parentheses refer to 95% confidence intervals. There were an additional 1065 deaths and 4313 hospitalizations that occurred during follow-up when participants were prescribed neither opiates nor NSAIDs (9.8 deaths per 1000 person-years and 44.4 hospitalizations per 1000 person-years). NSAID, nonsteroidal anti-inflammatory drug; MMEs, daily oral morphine milligram equivalents.