Table 3.

Examples of knowledge gaps in kidney disease relevant to kidney replacement strategies

Patient therapy preferences (setting, duration, etc.)
Patient-centric measures of adequate KRT
Biomarkers of adequate KRT
Amount of KRT needed to minimize uremic symptoms and consequences
Adequate animal uremic models that model human ESKD to test new products for safety and efficacy
Identification of critical kidney functions that must be replaced and which ones can be treated with drugs or managed in other ways