Table 2.

Performances of eGFR and functional magnetic resonance imaging measurements for the differentiation of ≤25% versus >25% interstitial fibrosis and >50% versus ≤50% interstitial fibrosis among kidney transplant patients with allograft injury

MeasurementsCorrelations with Interstitial Fibrosis≤25% versus >25% Interstitial Fibrosis>50% versus ≤50% Interstitial Fibrosis
CutoffAUC (95% CI)Sensitivity (95% CI)Specificity (95% CI)CutoffAUC (95% CI)Sensitivity (95% CI)Specificity (95% CI)
Apparent diffusion coefficientrho=−0.77; P<0.0011.99×10−3mm2/s0.87 (0.79 to 0.93)76% (62% to 87%)84% (70% to 93%)1.91×10−3mm2/s0.88 (0.80 to 0.93)86% (64% to 97%)72% (61% to 81%)
Arterial spin labelingrho=−0.83;; P<0.001101 ml/min per 100 g0.92 (0.85 to 0.97)94% (85% to 99%)78% (63% to 88%)82.9 ml/min per 100 g0.94 (0.87 to 0.98)95% (76% to 99.9%)87% (77% to 93%)
Perfusion fractionrho=−0.66 P<0.0010.2990.81 (0.72 to 0.88)a76% (62% to 87%)78% (63% to 88%)0.2850.86 (0.78 to 0.92)91% (70% to 99%)72% (61% to 81%)
BOLDrho=0.61; P<0.00118.10 Hz0.79 (0.69 to 0.87)b79% (64% to 89%)72% (57% to 84%)18.14 Hz0.85 (0.76 to 0.92)91% (70% to 99%)69% (58% to 80%)
eGFRcrho=−0.79; P<0.00138 ml/min per 1.73 m20.91 (0.84 to 0.96)91% (80% to 97%)78% (63% to 88%)38 ml/min per 1.73 m20.91 (0.84 to 0.96)95% (76% to 99.9%)72% (61% to 81%)
eGFRdrho=−0.79; P<0.00138 ml/min per 1.73 m20.93 (0.85 to 0.97)89% (77% to 97%)83% (69% to 92%)38 ml/min per 1.73 m20.90 (0.82 to 0.95)95% (76% to 99.9%)68% (56% to 79%)
  • eGFR calculated by the CKD Epidemiology Collaboration equation AUC, area under the curve; 95% CI, 95% confidence interval; BOLD, blood oxygen level–dependent.

  • a Represented P<0.05 by comparing the AUC of perfusion fraction to that of eGFR.

  • b Denoted P<0.01 by comparing the AUC of BOLD to that of eGFR.

  • c Indicated that data were analyzed from all 103 patients with allograft injury.

  • d Denoted that data were analyzed from 93 patients with BOLD results.