Table 1.

Demographic, genetic, and clinical characteristics of the study population with or without an intracranial aneurysm at the initial screening

VariableOverall, n=812With, n=75Without, n=737
Sex (% men:women)353:459 (43:57)26:49 (35:65)327:410 (44:56)
Mean age at the first MRA (SD), yr51 (13)51 (11)51 (13)
Age group, yr, n (%)
 30–39138 (17)8 (11)130 (18)
 40–49231 (28)27 (36)204 (28)
 50–59238 (29)21 (28)217 (29)
 60–69205 (25)19 (25)186 (25)
Race, n (%)
White730 (90)66 (88)664 (90)
Other42 (5)3 (4)39 (5)
Not reported40 (5)6 (8)34 (5)
Genotype available, n (%)360 (44)41 (55)319 (43)
PKD1 truncating173 (48)20 (49)153 (48)
PKD1 nontruncating111 (31)11 (27)100 (31)
PKD238 (11)7 (17)31 (10)
 Other7 (2)0 (0)7 (2)
 NMD31 (9)3 (7)28 (9)
Hypertension, n (%)631 (78)67 (90)564 (77)
Dyslipidemia, n (%)393 (48)33 (44)360 (49)
Smoking history, n (%)197 (24)32 (43)167 (23)
CKD stage, n (%)
 1–2253 (31)11 (15)242 (33)
 3–4326 (41)45 (63)281 (38)
 ESKD226 (28)16 (22)210 (29)
Family history of intracranial aneurysm (%)160 (20)28 (37)132 (18)
 Unruptured only59 (7)6 (8)53 (7)
 Ruptured/subarachnoid hemorrhage101 (12)22 (29)79 (11)
 None652 (80)47 (63)605 (82)
  • MRA, magnetic resonance angiography; NMD, no mutation detected.