Table 3.

Gram-positive antibiotic spectrum of activity and infectious diseases treated (23)

Antibiotic ClassSpectrum of ActivityCommonly Treated Infectious Diseases
Gram-PositiveGram-Negative
VancomycinStreptococci +++No activityBloodstream infections
MSSA/MRSA +++Clostridium difficile colitis (oral)
Staphylococcus epidermidis +++Endocarditis
Enterococcus faecalis +++Osteomyelitis
Enterococcus faecium +Pneumonia, hospital-acquired or ventilator-associated
Sepsis and septic shock
Skin/skin structure infections
LipopeptidesSee vancomycin, plus VRE, VISA/VRSANo activityBloodstream infections
 DaptomycinEndocarditis
Osteomyelitis
OxazolidinonesSee vancomycin, plus VRE, VISA/VRSAEnterococcal infections (VRE), including bacteremia (linezolid)
 LinezolidPneumonia, hospital-acquired or ventilator-associated (linezolid)
 TedizolidSkin/skin structure infections
LipoglycopeptidesSee vancomycin, plus VRE, VISA/VRSABloodstream infections, Staphylococcus aureus (telavancin)
 TelavancinPneumonia, hospital-acquired or ventilator-associated (telavancin)
 DalbavancinSkin/skin structure infections
 Oritavancin
  • +++, excellent activity; MSSA, methicillin-susceptible Staphylococcus aureus; MRSA, methicillin-resistant Staphylococcus aureus; +, some activity; VRE, vancomycin-resistant enterococci; VISA/VRSA, vancomycin-intermediate Staphylococcus aureus/ vancomycin-resistant Staphylococcus aureus.