Table 2.

Risk of ESKD and mortality in older live kidney donors (n=24,533)

OutcomeESKDUnadjustedAdjustedMortalityUnadjustedAdjusted
No. of EventsCumulative IncidenceHR (95% CI)P ValueNo. of EventsCumulative IncidenceHR (95% CI)P Value
Overall240.3%2522.7%
Risk factorsa
 No hypertension160.2%Reference2122.5%Reference
 Hypertension80.8%3.04 (1.28 to 7.22)0.01403.5%1.18 (0.84 to 1.66)0.34
Age, per 5-yr increase1.26 (0.85 to 1.89)0.251.57 (1.41 to 1.76)<0.001
Sex
 Men120.4%Reference1323.4%Reference
 Women120.2%0.56 (0.24 to 1.29)0.171202.0%0.55 (0.43 to 0.72)<0.001
Race/ethnicity
 Nonwhite40.3%Reference362.0%Reference
 White200.3%1.18 (0.39 to 3.53)0.772162.8%1.21 (0.84 to 1.75)0.31
eGFR, per 10-unit decreaseb1.13 (0.82 to 1.56)0.460.97 (0.88 to 1.06)0.48
Biologically
 Unrelated80.2%Reference1192.6%Reference
 Related160.4%1.65 (0.70 to 3.89)0.251332.8%1.03 (0.80 to 1.32)0.79
  • HR, adjusted hazard ratio; 95% CI, 95% confidence interval; —, not applicable.

  • a Multivariable Cox regression to compare the risk of ESKD and mortality for 15 years postdonation in older (≥50 years old) donors with hypertension (n=2265) versus those without hypertension (n=22,268), accounting for age, sex, race/ethnicity, eGFR, and donor/recipient relationship.

  • b Imputed for 1% missing eGFR (n=234 eGFR values). Our inferences remained unchanged in the complete-data analysis (n=24,299).