Table 2.

Prevalence of hyponatremic overcorrection by 14 different published criteria

CriterionOvercorrection ThresholdPatients without Missing ValuesPatients Meeting Criteria for Overcorrection% Patients with Hyponatremic Overcorrection (95% CI)Mean (Range) Agreement with Other Criteria
A0.5 mmol/L per hour62356190 (87 to 92)−0.25 (−0.74 to 0.22)
B38 mmol/L per day62331050 (46 to 54)0.44 (−0.04 to 0.87)
B512 mmol/L per day62315224 (21 to 28)0.56 (−0.31 to 0.92)
C18 mmol/L per 2 days62310216 (13 to 19)0.49 (−0.47 to 0.94)
D8 mmol/L per day520448 (6 to 11)0.13 (−0.74 to 0.39)
E38 mmol/L per day62229247 (43 to 51)0.44 (−0.02 to 0.79)
E410 mmol/L per day62219331 (27 to 35)0.54 (−0.18 to 0.80)
E512 mmol/L per day62212520 (17 to 23)0.53 (−0.40 to 0.86)
F18 mmol/L per 2 days62310918 (14 to 20)0.50 (−0.45 to 0.86)
G38 mmol/L per day61332653 (49 to 57)0.39 (−0.12 to 0.87)
G410 mmol/L per day61324540 (36 to 44)0.51 (−0.02 to 0.75)
H18 mmol/L per 2 days55211020 (17 to 23)0.37 (−0.47 to 0.74)
I512 mmol/L per day62315926 (22 to 29)0.56 (−0.29 to 0.92)
I618 mmol/L per day62311118 (15 to 21)0.51 (−0.44 to 0.94)
  • Details regarding the criteria and overcorrection thresholds are described in Supplemental Table 2. Agreement with other criteria was measured using prevalence-adjusted and bias-adjusted κ-statistic (14). 95% CI, 95% confidence interval.