Table 3.

Baseline factors associated with hyponatremic overcorrection and the Severe Hyponatremic Overcorrection Risk score

FactorParameter Estimate (SEM)Adjusted Odds Ratio (95% CI)Points
UnlikelyPossibleDefiniteUnlikelyPossibleDefinite
Intercept5.09 (1.31)7.14 (0.189)19.37 (1.278)N/AN/AN/AN/A
Patient age, yr−0.1 (0.024)−0.1 (0.004)−0.39 (0.028)0.9 (0.86 to 0.95)0.9 (0.89 to 0.91)0.68 (0.64 to 0.72)N/A
 40–500
 50–60−1
 60–70−2
 70–80−3
 80–90−4
Vomiting0.07 (0.075)0.37 (0.011)0.63 (0.091)1.07 (0.92 to 1.24)1.45 (1.41 to 1.47)1.88 (1.57 to 2.25)2
Somnolent0.12 (0.086)0.13 (−0.002)0.68 (0.092)1.13 (0.96 to 1.34)1.14 (1.14 to 1.14)1.97 (1.66 to 2.37)2
Volume overloaded−1.05 (0.202)−1.23 (0.022)−1.8 (0.409)0.35 (0.24 to 0.52)0.29 (0.28 to 0.31)0.17 (0.07 to 0.37)−5
Corrected sodium, mmol/L−0.05 (0.012)−0.07 (0.002)−0.17 (0.011)0.95 (0.93 to 0.98)0.93 (0.93 to 0.93)0.84 (0.83 to 0.87)N/A
 <1104
 110 to <1122
 112 to <1141
 114–1160
K+ <3.0 mmol0.72 (0.08)0.77 (0.009)0.49 (0.106)2.05 (1.76 to 2.41)2.16 (2.12 to 2.2)1.63 (1.32 to 2)1
Uosm <150 mosm/kg0.76 (0.119)0.42 (0.081)1.39 (0.108)2.14 (1.7 to 2.71)1.52 (1.29 to 1.78)4.01 (3.27 to 4.98)4
Chest tumor−0.8 (0.131)−0.81 (0.029)−1.85 (0.29)0.45 (0.35 to 0.58)0.44 (0.42 to 0.47)0.16 (0.09 to 0.28)−5
  • Parameter estimates and adjusted odds ratios are compared with the no overcorrection group. Presented values are the mean of 1000 bootstrap samples. 95% CI, 95% confidence interval; N/A, not applicable; K+, potassium; Uosm, urinary osmolarity.