Table 4.

Miscellaneous antibiotic spectrum of activity and infectious diseases treated (41,51)

Antibiotic ClassSpectrum of ActivityCommonly Treated Infectious Diseases
Gram-PositiveGram-Negative
AminoglycosidesSynergy onlyEnterobacteriaceae ++Endocarditis
 AmikacinEnterococcus sp.Pseudomonas aeruginosa ++Pneumonia, hospital-acquired or ventilator-associated
 GentamicinMSSAHaemophilus influenzae +Urinary tract infections
 TobramycinMoraxella catarrhalis +Pyelonephritis
Synergy (Gram-positive infections)
FluoroquinolonesStreptococci +++ (L, M, D)Moraxella catarrhalis +++ (except D)Intra-abdominal infections
 Ciprofloxacin (C)MSSA/MRSA +++ (D)Haemophilus influenza +++ (L, M)Osteomyelitis (C)
 Delafloxacin (D)Enterococcus faecalis +++ (D)Escherichia coli +++Pneumonia, community-acquired (L, M)
 Ofloxacin (O)ESBL Escherichia coli +++Pneumonia, hospital-acquired or ventilator-associated (C, L)
 Levofloxacin (L)Klebsiella sp. +++Prostatitis (C, L)
 Moxifloxacin (M)Proteus sp. +++ (except D)Urinary tract infections (except moxifloxacin)
Serratia sp. +++ (except D)Pyelonephritis (except M)
Enterobacter sp. +++Skin/skin structure infections (D)
Citrobacter sp. +++ (except D)Atypical coverage: Legionella sp., Mycoplasma pneumoniae, Chlamydophila sp.
Pseudomonas aeruginosa ++ (except M)
Bacteroides fragilis ++ (M)
Sulfamethoxazole-trimethoprimMSSA/MRSA +++Escherichia coli ++Skin/soft tissue infections
Staphylococcus epidermidis +++ESBL Escherichia coli ++Urinary tract infections
Streptococcus pyogenes +++Klebsiella sp. ++Pyelonephritis
Streptococcus pneumoniae +Serratia sp. ++Pneumocystis pneumonia
Proteus sp. ++Upper respiratory tract infections
  • ++, good activity; MSSA, methicillin-sensitive Staphylococcus aureus; +, some activity; L, levofloxacin; M, moxifloxacin; D, delafloxacin; +++, excellent activity; C, ciprofloxacin; MRSA, methicillin-resistant Staphylococcus aureus; O, ofloxacin; ESBL, extended-spectrum β-lactamases.