Table 1.

Pharmacodynamics of common antibiotic classes (5,6)

Antibiotic ClassPharmacodynamic ProfilePharmacodynamic Parameter to Optimize
AminoglycosidesConcentration-dependentPeak:MIC
PenicillinsTime-dependentTime>MIC
CephalosporinsTime-dependentTime>MIC
CarbapenemsTime-dependentTime>MIC
VancomycinTime-dependentAUC:MIC
LipopeptidesConcentration-dependentAUC:MIC; peak:MIC
OxazolidinonesTime-dependentAUC:MIC
LipoglycopeptidesConcentration-dependentAUC:MIC
FluoroquinolonesConcentration dependentAUC:MIC
MacrolidesTime-dependentAUC:MIC
Sulfamethoxazole-trimethoprimLimited data (65)Limited data (65)
  • Peak:MIC, maximum concentration (peak)-to-minimum inhibitory concentration ratio; Time>MIC, percentage of the dosing interval that concentrations stay above the minimum inhibitory concentration; AUC:MIC, drug exposure (area under the curve)-to-minimum inhibitory concentration ratio.