Table 2.

Bone histomorphometric parameters of participants in a longitudinal bone biopsy study who underwent kidney transplantation

Bone ParameterAll Kidney Transplant Recipients
at Baseline,
n=37Kidney Transplant Recipients with Repeat Bone Biopsy, n=27
At BaselineTwo Years after Kidney TransplantationP Valuea
Bone formation rate/bone surface (μm3/μm2 per year)21.1 (13.7–44.2)b20.3 (13.4–43.4)c10.4 (6.1–27.1)0.02a
Activation frequency (1/yr)0.6 (0.2–1.1)b0.5 (0.1–1.0)c0.3 (0.1–0.6)0.13
Osteoblastic surface/bone surface (Z-score)0.2 (−3.2 to 5.5)d1.6 (−2.5 to 6.2)−2.2 (−2.6 to −0.6)0.008a
Osteoclastic surface/bone surface (Z-score)3.2 (−2.1 to 13.8)d9.9 (−1.5 to 13.8)−0.2 (−2.3 to 2.5)0.002a
Osteoid surface/bone surface, %39.1 (32.9–53)d40.2 (34–53.9)34.1 (20.4–46.1)0.08
Osteoid thickness, µm6.9 (5.7–8.6)d7.3 (6.3–9.1)8.9 (7.6–10.6)0.02a
Mineralization lag time, d40.6 (27.6–110.2)b47.7 (28.7–117.5)c69.3 (42.8–162.8)0.66
Bone volume/tissue volume, %22.3 (14.3–26.5)d22.2 (13.9–26.8)20.7 (13.6–27.8)0.98
Lumbar spine T-score−0.7 (−1.6 to 0.4)e−0.8 (−1.6 to 0.3)f−0.4 (−1.3 to 0.5)g0.41
Femoral neck T-score−1.1 (−1.8 to −0.1)e−1.6 (−2.0 to −0.8)f−1.9 (−2.7 to −1.2)g0.03a
  • All values are expressed as median (interquartile range).

  • a P value compares values 2 years after transplantation to values at baseline among kidney transplant recipients with repeat bone biopsy.

  • b n=25.

  • c n=23.

  • d n=32.

  • e n=36.

  • f n=26.

  • g n=22.