Bone histomorphometric parameters of participants in a longitudinal bone biopsy study who underwent kidney transplantation
Bone Parameter | All Kidney Transplant Recipients at Baseline, n=37 | Kidney Transplant Recipients with Repeat Bone Biopsy, n=27 | ||
---|---|---|---|---|
At Baseline | Two Years after Kidney Transplantation | P Valuea | ||
Bone formation rate/bone surface (μm3/μm2 per year) | 21.1 (13.7–44.2)b | 20.3 (13.4–43.4)c | 10.4 (6.1–27.1) | 0.02a |
Activation frequency (1/yr) | 0.6 (0.2–1.1)b | 0.5 (0.1–1.0)c | 0.3 (0.1–0.6) | 0.13 |
Osteoblastic surface/bone surface (Z-score) | 0.2 (−3.2 to 5.5)d | 1.6 (−2.5 to 6.2) | −2.2 (−2.6 to −0.6) | 0.008a |
Osteoclastic surface/bone surface (Z-score) | 3.2 (−2.1 to 13.8)d | 9.9 (−1.5 to 13.8) | −0.2 (−2.3 to 2.5) | 0.002a |
Osteoid surface/bone surface, % | 39.1 (32.9–53)d | 40.2 (34–53.9) | 34.1 (20.4–46.1) | 0.08 |
Osteoid thickness, µm | 6.9 (5.7–8.6)d | 7.3 (6.3–9.1) | 8.9 (7.6–10.6) | 0.02a |
Mineralization lag time, d | 40.6 (27.6–110.2)b | 47.7 (28.7–117.5)c | 69.3 (42.8–162.8) | 0.66 |
Bone volume/tissue volume, % | 22.3 (14.3–26.5)d | 22.2 (13.9–26.8) | 20.7 (13.6–27.8) | 0.98 |
Lumbar spine T-score | −0.7 (−1.6 to 0.4)e | −0.8 (−1.6 to 0.3)f | −0.4 (−1.3 to 0.5)g | 0.41 |
Femoral neck T-score | −1.1 (−1.8 to −0.1)e | −1.6 (−2.0 to −0.8)f | −1.9 (−2.7 to −1.2)g | 0.03a |