Table 2.

Incidence of major adverse kidney events within 30 days by primary and sensitivity analyses

PermutationNMAKE30 (95% CI)Mortality, n (%)KRT, n (%)PKD, n (%)
Baseline creatinine measured or imputed using median normal value for age and sex
 Primary analysis16859.6% (8.1 to 11.0)75 (4.5)29 (1.7)98 (5.8)
 Measured baseline creatinine only9889.8% (7.9 to 11.7)44 (4.5)12 (1.2)68 (6.9)
 Imputed baseline creatinine for all patients16858.7% (7.3 to 10.0)75 (4.5)29 (1.7)83 (4.9)
 First hospitalization only14609.8% (8.4 to 11.4)67 (4.6)28 (1.9)85 (5.8)
 Admitted through ED only14098.9% (7.4 to 10.4)55 (3.9)24 (1.7)73 (5.2)
 Excluding patients with existing ESKD16659.5% (8.1 to 11.0)73 (4.4)29 (1.7)98 (5.9)
Baseline creatinine measured or imputed using upper limit of normal value for age and sex16859.1% (7.7 to 10.5)75 (4.5)29 (1.7)89 (5.3)
Baseline creatinine measured or imputed using multiple imputations16859.6% (8.2 to 11.0)75 (4.5)29 (1.7)95 (5.6)
  • Multiple imputation strategy included the following variables: age, sex, race, chronic comorbid conditions, and minimum serum creatinine measured within the first 7 days of hospitalization. MAKE30, major adverse kidney events within 30 days; 95% CI, 95% confidence interval; KRT, kidney replacement therapy; PKD, persistent kidney dysfunction (defined as at least doubling of the baseline serum creatinine at hospital discharge or hospital day 30, whichever came first); ED, emergency department.