Table 2.

Selected drugs with kidney function cutoffs for eligibility and dose modifications

DrugKidney Function Cutoff Below Which Not to Treat, ml/minKidney Function Ranges with Dose Modifications, ml/minReference
Bendamustine3042
Bleomycin5%–10% to 40%41
10%–20% to 45%
20%–30% to 55%
30%–40% to 60%
40%–50% to 70%
Capecitabine3030%–50% to 75%43
Cisplatin6037
Etoposide1515%–50% to 75%44
Fludarabine3030%–49% to 60%45
50%–79% to 80%
Methotrexate6046
Mitomycin30a47
Oxaliplatin<30%–75%48
Pemetrexed4549
Pentostatin50%–60% to 50%50
Topotecan1020%–39% to 50%51
  • —, not applicable.

  • a Related to hydroxypropyl-β-cyclodextrin excipient.