Table 3.

Randomized trials comparing the effect of icodextrin versus glucose-containing dialysate solutions on BP in patients on peritoneal dialysis

AuthorYearNPatient CharacteristicsDesignFollow-Up, moInterventionEffect on Body WeightEffect on UF VolumeEffect on BP
Woodrow et al. (47)200014Patients on APDCrossover1Icodextrin versus 2.27% glucose dialysate in daytime dwellIcodextrin lowered BP by 19.5/6.0 mm Hg, despite the parallel reduction in antihypertensive drugs in six out of 14 participants
Plum et al. (46)200239Patients on APDParallel3Icodextrin versus 2.27% glucose dialysate in daytime dwellNo difference
Konings et al. (44)200340Patients on CAPD or APDParallel4Icodextrin versus standard dialysate glucose during the long dwellNo difference
Davies et al. (43)200350Hypertensive patients on CAPD or APDParallel6Icodextrin versus 2.27% glucose dialysate during the long dwellNo difference in BP levels, but icodextrin-treated participants required fewer antihypertensive medications during follow-up
Paniagua et al. (45)200859Diabetic patients on CAPDParallel12Icodextrin versus 2.27% glucose dialysate during the long night-time dwellIcodextrin lowered BP by 10.4/6.2 mm Hg versus 2.27% glucose dialysate (P<0.01)
  • UF, ultrafiltration; APD, automated peritoneal dialysis; ↓ , significant reduction in icodextrin groups relative to control group; CAPD, continuous ambulatory peritoneal dialysis.