Table 2.

Electrolyte serum concentrations and 24-hour creatinine-normalized urine excretion at baseline and week 4 in patients with baseline serum phosphate >4.8 mg/dl (hyperphosphatemia) and baseline serum phosphate ≤4.8 mg/dl

ParameterBaselineWeek 4Change from Baseline to Week 4
Mean (SD)NMean (SD)NMean (SD)N
Patients with baseline serum phosphate >4.8 mg/dl
 Serum electrolytes, mg/dl
  Calciuma9.1 (0.5)169.3 (0.3)130.1 (0.4)13
  Magnesium2.3 (0.4)162.1 (0.4)13−0.1 (0.1)13
  Phosphate5.3 (0.4)164.7 (0.9)13−0.6 (0.8)13
 24-h creatinine-normalized urine electrolytes, mg/24 h
  Calcium30.5 (19.9)632.3 (20.0)61.8 (12.3)6
  Phosphate722.8 (331.9)9573.7 (304.7)9−149.1 (162.6)9
Patients with baseline serum phosphate ≤4.8 mg/dl
 Serum electrolytes, mg/dl
  Calciuma9.4 (0.6)959.5 (0.6)870.0 (0.5)87
  Magnesium2.1 (0.3)952.0 (0.3)87−0.2 (0.2)87
  Phosphate3.9 (0.6)953.9 (0.6)870.0 (0.6)87
 24-h creatinine-normalized urine electrolytes, mg/24 h
  Calcium52.7 (56.9)6760.7 (61.2)729.3 (44.6)63
  Phosphate604.8 (277.5)94573.6 (286.1)86−49.9 (194.4)86
  • a Serum albumin-corrected calcium performed according to the following: if serum albumin ≥4.0 g/dl, corrected calcium=serum calcium; if serum albumin <4.0 g/dl, corrected calcium=serum calcium+(0.8×[4−serum albumin]). For calculations, calcium units were milligrams per deciliter and albumin units were grams per deciliter.