Table 1.

Studies examining corticosteroid therapy in acute tubulointerstitial nephritis

Author, Year (Reference)Sample SizePeak sCr, mg/dlFinal sCr, mg/dlFollow-Up, moComment
SteroidNo SteroidSteroidNo SteroidSteroidNo Steroid
Clarkson et al. (11)26167. received CS late after diagnosis (median delay >3 wk)
González et al. (4)5295. patients with complete recovery had shorter delay to CS (13 d) compared with those without complete recovery (34 d)
Raza et al. (5)37126. eGFR with CS versus control (P<0.05); no difference in kidney outcomes on the basis of CS timing
Muriithi et al. (6)83123. patients had better kidney outcomes with early versus late CS therapy
Valluri et al. (7)73514.033.16N/AN/A12Worse kidney function in CS-treated patients versus controls at biopsy (sCr 4.2 versus 3.3 mg/dl); CS-treated patients had complete recovery (48%) versus control group (41%); final sCr was not different at 1 yr
Prendecki et al. (3)1582921 ml/min (eGFR)25 ml/min (eGFR)43 ml/min (eGFR)24 ml/min (eGFR)24CS-treated patients had better eGFR at 2 yr and less dialysis (5% versus 24%); dose, duration, and time to CS initiation were variable
Fernandez-Juarez et al. 2018 (8)18205.7N/A1.7–2.2N/A6Duration of CS therapy was not associated with 6-mo recovery of eGFR; shorter interval between diagnosis and CS initiation was associated with greater recovery of kidney function at 6 mo
  • sCr, serum creatinine concentration; CS, corticosteroid; N/A, not available.