Table 3.

Corticosteroid treatment and recovery of kidney function at month 6 after drug-induced AIN injury

VariablesGlobal n=182Complete Recovery n=75Partial Recovery n=83Nonrecovery n=24P Value
Interval between AIN diagnosis and offending drug discontinuation, da6 (1–13)5 (1–13)6 (1–13)11 (4–36)0.1
Interval between AIN diagnosis and start of corticosteroids, da12 (4–22)9 (2–17)b12 (5–22)c29/12–44)0.008
 Interval between AIN diagnosis and start of corticosteroids <15 d110 (61)51 (70)52 (63)7 (29)0.002
 Interval between AIN diagnosis and start of corticosteroids <21 d129 (71)60 (82)60 (72)9 (37)<0.001
Intravenous pulse corticosteroids88 (48)33 (45)46 (55)9 (37)0.23
Initial corticosteroid dose, mg/kg per day0.8±0.20.8±0.20.83±0.170.9±0.20.8
Duration of high-dose corticosteroid treatment, wka2 (1–4)2 (1–4)2 (1–4)1.5 (1–3)0.8
Total duration of corticosteroid treatmenta9 (7–13)9 (7–12.5)9 (7–14)9 (7–20)0.6
  • Complete recovery: Scr at 6 months did not exceed baseline Scr by >25%. Partial recovery: Scr at 6 months exceeded baseline Scr by 25%–75%. Nonrecovery: Scr at 6 months exceeded baseline Scr by >75% or required maintenance dialysis. AIN, acute interstitial nephritis; AIN, drug-induced acute interstitial nephritis; Scr, serum creatinine.

  • a Median (interquartile range).

  • b P=0.001 complete recovery versus partial recovery.

  • c P=0.001 partial recovery versus non-recovery.