Table 1.

Baseline characteristics of patients admitted to the University of Pittsburgh Medical Center with hyponatremia and treated with urea between July 2016 and August 2017

CharacteristicN=58
Demographic characteristics
 Median age [IQR], yr68 [55–79]
 Men, N (%)35 (60.3)
Clinical and treatment characteristics
 Etiology of hyponatremia, N (%)
  SIADHb47 (81)
   Medications18 (31)
   Idiopathic13 (22)
   Intracranial disorders13 (22)
   Malignancy10 (17)
   Pulmonary disorders8 (14)
   Pain7 (12)
   Other2 (3)
  Thiazide diuretics7 (12)
  Heart failure6 (10)
  Hypovolemia6 (10)
  Kidney disease4 (7)
  Adrenal insufficiency2 (3)
  Cirrhosis1 (2)
 Other therapies for hyponatremia, N (%)
  Fluid restriction51 (88)
  Sodium chloride tablets22 (38)
  Loop diuretics19 (33)
  Normal saline12 (21)
  Vasopressin antagonists6 (10)
  Hypertonic saline 3%4 (7)
  Potassium chloride tablets3 (5)
  Glucocorticoids1 (2)
  • Etiologies of hyponatremia and therapies for hyponatremia are not mutually exclusive. IQR, interquartile range; SIADH, syndrome of inappropriate antidiuretic hormone secretion.