Table 4.

Incidence of long-term kidney outcomes according to initial randomization to intensive BP control (systolic BP <120 mm Hg), stratified by sex and also by white race

OutcomeaWomenMenWhite RaceNonwhite Race
n=2191 (1089 Intensive; 1102 Standard)n=2425 (1219 Intensive; 1206 Standard)n=2808 (1382 Intensive, 1426 Standard)n=3487
Event NumberHR/SHR (95% CI)Event NumberHR/SHR (95% CI)Event NumberHR/SHR (95% CI)Event NumberHR/SHR (95% CI)
Composite kidney outcome352 Int1.27 (1.09 to 1.49)c417 Int1.07 (0.94 to 1.23)503 Int1.11 (0.98 to 1.26)266 Int1.26 (1.06 to 1.51)c
300 Std400 Std456 Std244 Std
Macroalbuminuriab86 Int0.86 (0.64 to 1.18)126 Int,1.04 (0.81 to 1.34)
89 Std124 Std
Doubling of creatinine169 Int2.13 (1.63 to 2.77)c72 Int1.17 (0.84 to 1.63)
86 Std70 Std
Dialysis28 Int0.90 (0.52 to 1.56)43 Int0.89 (0.55 to 1.45)
34 Std44 Std
All-cause mortality265 Int0.92 (0.78 to 1.09)133 Int1.24 (0.97 to 1.59)
282 Std114 Std
  • HR, hazard ratio; SHR, subhazard ratio; 95% CI, 95% confidence interval; Int, intensive; Std, standard; —, analysis not performed because interaction term was not significant.

  • a HRs and 95% CIs are for fully adjusted multivariable analyses using contrast statements from models with participants from both subtrials.

  • b Denominators for macroalbuminuria outcome among women: 965 intensive, 966 standard; among men: 1081 intensive, 1063 standard; among whites: 1249 intensive, 1274 standard; among nonwhites: 797 intensive, 755 standard.

  • c Statistically significant results.