Outcome^{a} | Women | Men | White Race | Nonwhite Race | ||||
---|---|---|---|---|---|---|---|---|

n=2191 (1089 Intensive; 1102 Standard) | n=2425 (1219 Intensive; 1206 Standard) | n=2808 (1382 Intensive, 1426 Standard) | n=3487 | |||||

Event Number | HR/SHR (95% CI) | Event Number | HR/SHR (95% CI) | Event Number | HR/SHR (95% CI) | Event Number | HR/SHR (95% CI) | |

Composite kidney outcome | 352 Int | 1.27 (1.09 to 1.49)^{c} | 417 Int | 1.07 (0.94 to 1.23) | 503 Int | 1.11 (0.98 to 1.26) | 266 Int | 1.26 (1.06 to 1.51)^{c} |

300 Std | 400 Std | 456 Std | 244 Std | |||||

Macroalbuminuria^{b} | 86 Int | 0.86 (0.64 to 1.18) | 126 Int, | 1.04 (0.81 to 1.34) | — | — | ||

89 Std | 124 Std | |||||||

Doubling of creatinine | — | — | 169 Int | 2.13 (1.63 to 2.77)^{c} | 72 Int | 1.17 (0.84 to 1.63) | ||

86 Std | 70 Std | |||||||

Dialysis | 28 Int | 0.90 (0.52 to 1.56) | 43 Int | 0.89 (0.55 to 1.45) | — | — | ||

34 Std | 44 Std | |||||||

All-cause mortality | — | — | 265 Int | 0.92 (0.78 to 1.09) | 133 Int | 1.24 (0.97 to 1.59) | ||

282 Std | 114 Std |

HR, hazard ratio; SHR, subhazard ratio; 95% CI, 95% confidence interval; Int, intensive; Std, standard; —, analysis not performed because interaction term was not significant.

↵a HRs and 95% CIs are for fully adjusted multivariable analyses using contrast statements from models with participants from both subtrials.

↵b Denominators for macroalbuminuria outcome among women: 965 intensive, 966 standard; among men: 1081 intensive, 1063 standard; among whites: 1249 intensive, 1274 standard; among nonwhites: 797 intensive, 755 standard.

↵c Statistically significant results.