Table 2.

Kidney function measurement according to age group

VariablesAge, yr
18–2930–3940–4950–59≥60P for Trend
ADPKDControlADPKDControlADPKDControlADPKDControlADPKDControlADPKDControl
N17172626414150501616
eGFR, ml/min per 1.73 m2110±22113±1185±20a98±1358±25a91±1050±21a86±1235±21a83±13<0.001<0.001
Measured GFR, ml/min per 1.73 m2103±21111±990±18a109±1062±25a104±1553±21a97±1438±19a89±19<0.001<0.001
Effective kidney plasma flow, ml/min per 1.73 m2317±78346±42260±44a346±58192±76a326±51169±66a299±46123±49a282±57<0.001<0.001
Kidney blood flow, ml/min per 1.73 m2548±139626±74455±83a623±94311±124a577±103285±111a532±87228±104a511±112<0.001<0.001
Kidney vascular resistance, dynes/s per centimeter (5)11,291 (10,174–16,077)b10,070 (9238–11,092)13,377a (12,419–15,777)9617 (8874–11,100)21,659a (17,134–28,200)11,344 (9574–12,657)24,723a (18,214–32,332)12,378 (11,016–14,530)27,454a (20,970–50,899)13,547 (11,658–16,424)<0.001<0.001
Kidney function reserve capacity, %11.1±8.3b5.3±6.53.8±5.6a9.9±8.24.3±9.2a11.8±7.62.6±11.4a9.4±10.2−0.1±8.8a9.8±6.30.0010.18
Filtration fraction, %33.5±4.432.7±4.934.5±4.1b32.2±4.232.2±4.232.2±3.631.1±3.8b32.8±3.829.6±4.131.9±3.8<0.0010.75
  • Variables are presented as mean±SD, or as median (interquartile range) in case of non-normal distribution. P values are obtained using one-way ANOVA in case of normal distribution and Kruskal–Wallis test in case of non-normal distribution. ADPKD, autosomal dominant polycystic kidney disease; —, not applicable.

  • a P<0.001 compared with healthy control same age group.

  • b P<0.05 compared with healthy control same age group.