Table 3.

Incidence of long-term kidney outcomes according to initial randomization to intensive glycemic control (hemoglobin A1c <6.0%), stratified by sex

OutcomeaWomenMen
n=3825 (1917 Intensive; 1908 Standard)n=6146 (3075 Intensive; 3071 Standard)
Event NumberHR/SHR (95% CI)Event NumberHR/SHR (95% CI)
Composite outcome579 Int1.0 (0.89 to 1.12)1036 Int0.88 (0.81 to 0.95)c
589 Std1131 Std
Macroalbuminuriab150 Int0.83 (0.66 to 1.05)258 Int0.61 (0.51 to 0.71)c
170 Std394 Std
Dialysis67 Int1.11 (0.76 to 1.62)94 Int0.83 (0.61 to 1.13)
57 Std129 Std
  • HR, hazard ratio; SHR, subhazard ratio; 95% CI, 95% confidence interval; Int, intensive; Std, standard.

  • a HRs and 95% CIs are for fully adjusted multivariable analyses.

  • b Denominators for macroalbuminuria outcome among women: 1664 intensive, 1689 standard; among men: 2688 intensive, 2704 standard.

  • c Statistically significant results.