Table 4.

Circulating markers of oxidative stress, inflammation, and lipid mediators in participants with autosomal dominant polycystic kidney disease and control participants

VariableADPKD, n=61Control, n=19P Value
hsCRP, mg/L1.09 (0.38–3.39)1.36 (0.46–2.55)0.77
IL-6, pg/ml0.56 (0.37–0.92)0.48 (0.33–0.67)0.29
8-Isoprostane, pg/ml4.9 (3.8–6.2)4.6 (3.7–6.0)0.51
PGF2α. pg/ml27.4 (13.0–67.1)29.2 (20.3–46.8)0.60
PGD2, pg/ml83.9 (49.4–128.6)78.8 (60.9–108.6)0.41
PGE2, pg/ml150.2 (52.4–389.1)182.9 (139.6–210.2)0.36
9-HODE, ng/ml12.7 (7.2–20.4)11.9 (10.2–18.1)0.55
13-HODE, ng/ml10.5 (6.8–17.2)17.7 (10.9–27.0)0.04
5-HETE, ng/ml2.1 (0.80–3.0)1.9 (1.2–3.2)0.32
8-HETE, ng/ml2.0 (1.2–2.9)0.71 (0.53–0.89)0.57
9-HETE, ng/ml2.0 (1.0–5.1)1.6 (1.2–2.5)0.20
11-HETE, ng/ml1.1 (0.61–2.8)1.5 (1.0–2.1)0.58
12-HETE, ng/ml43.6 (22.5–110.1)46.2 (22.4–92.7)0.87
11,12-EET, ng/ml1.3 (0.47–3.4)1.6 (1.1–2.1)0.58
14,15-EET, ng/ml1.0 (0.67–2.0)1.4 (0.9–1.7)0.48
5-HEPE, ng/ml0.71 (0.46–0.95)0.61 (0.37–0.72)0.19
12-HEPE, ng/ml28.4 (11.4–71.2)36.4 (27.2–68.8)0.20
  • Data are median (interquartile range). P values are independent t test comparisons between groups using log-transformed variables. ADPKD, autosomal dominant polycystic kidney disease; hsCRP, high-sensitivity C-reactive protein; PG, prostaglandin; HODE, hydroxyoctadecadienoic acid; HETE, hydroxyeicosatetraenoic acid; EET epoxyeicosatrienoic acid, HEPE, hydroxyeicosapentanoic acid.