Table 3.

Characteristics of patients according to genotype at rs219755, located in block B, in all 393 patients and 370 patients undergoing the sodium chloride infusion test

VariablesAAGAGGP Value
N (men/women)22 (18/4)157 (125/32)214 (174/40)0.91
 Age, yr44±1044±1144±90.96
 Body mass index, kg/m224.2±2.725.7±2.725.5±3.00.47
 History of stones, n (%)1 (5)15 (10)17 (8)0.68
 Patients who were hypercalciuric, n (%)2 (9)34 (22)66 (31)a0.02
 eGFR, ml/min per 1.73 m289±1892±1692±160.88
 Serum calcium, mg/dl9.2±0.49.2±0.49.2±0.40.73
 Urine calcium excretion, mg/24 h124±73b194±100c225±124<0.001
 Urine sodium excretion, mmol/24 h129±59141±65151±680.05
 Basal mean BP, mm Hg109±12106±11108±120.35
N (men/women)20 (17/3)148 (117/31)202 (167/35)0.63
 Urinary calcium before NaCl infusion from −120 to 0 min, mg/2 h14±1720±1722±200.12
 Urinary calcium during NaCl infusion from 0 to 120 min, mg/2 h17±11d29±1830±210.03
 Urinary calcium after NaCl infusion from 120 to 240 min, mg/2 h15±1318±1419±170.36
 Serum calcium at the end of NaCl infusion, mg/dl8.2±0.58.2±0.68.1±0.70.60
 Serum calcium at the end of test, mg/dl8.4±0.48.5±0.48.4±0.50.50
 Urinary sodium before NaCl infusion from −120 to 0 min, μmol/2 h13±2215±1316±130.61
 Urinary sodium during NaCl infusion from 0 to 120 min, μmol/2 h41±2955±3152±280.65
 Urinary sodium after NaCl infusion from 120 to 240 min, μmol/2 h43±2155±3159±280.78
 Mean BP increment at the end of NaCl infusion, mm Hg0.4±6.71.8±5.92.1±7.10.50
 Mean BP increment at the end of test, mm Hg3.5±9.13.0±9.83.1±9.50.78
  • P value for genotype-phenotype association was estimated with linear regression. Comparisons between groups were performed with one-way ANOVA and Tukey test.

  • a P=0.05 versus patients with genotype GA and P=0.05 versus patients with genotype AA.

  • b P=0.04 versus patients with genotype GA and P=0.001 versus patients with genotype GG.

  • c P=0.04 versus patients with genotype AA and P=0.04 versus patients with genotype GG.

  • d P=0.04 versus patients with genotype GA and P=0.01 versus patients with genotype GG.