Table 2.

Vascular parameters in participants with autosomal dominant polycystic kidney disease and control participants

VariableADPKD, n=61Control, n=19P Value
FMDBA, mm0.26±0.150.32±0.130.15
Baseline FMD diameter, mm3.5±0.73.2±0.50.13
Shear rate, s−11075±4591134±3060.20
Brachial artery dilation to nitroglycerin, %28.3±7.330.1±7.30.46
Baseline nitroglycerin diameter, mm3.5±0.73.3±0.470.29
Carotid-radial PWV, cm/s921±157813±136<0.008
Carotid artery compliance, (mm/mm Hg) ×10−10.12±0.040.12±0.040.50
Carotid β-stiffness index, AU6.0±2.05.4±1.30.20
Carotid IMT, mm0.48±0.080.45±0.050.23
Carotid systolic BP, mm Hg119±15106±130.001
Mean arterial BP, mm Hg91±980±6<0.001
  • Data are mean±SD. In total, n=12 control participants and n=37 participants with ADPKD were administered nitroglycerin, and n=60 participants with ADPKD and all (n=19) control participants had measurements of carotid artery compliance, β-stiffness index, and carotid IMT. ADPKD, autosomal dominant polycystic kidney disease; FMDBA, brachial artery flow-mediated dilation; FMD, flow-mediated dilation; PWV, pulse-wave velocity; IMT, intimal medial thickness.