Table 2.

Effects of increasing dialysate magnesium on T50 and related biomarkers

VariableBaselineFollow-UpChange from Baseline to Follow-Up (95% CI)Between-Group Difference at Follow-Up (95% CI)P Value for Difference at Follow-Up
T50, min73 (30 to 116)0.001
 Standard dialysate Mg233±81229±93−4 (−26 to 17)
 High dialysate Mg247±69302±6654 (31 to 78)a
Mg, mg/dl0.9 (0.7 to 1.1)0.001
 Standard dialysate Mg2.4±0.32.5±0.30.1 (−0.0 to 0.2)
 High dialysate Mg2.4±0.43.4±0.50.9 (0.8 to 1.1)a
PO4, mg/dl−0.4 (−1.0 to 0.3)0.24
 Standard dialysate Mg5.0±1.34.9±1.3−0.1 (−0.5 to 0.3)
 High dialysate Mg4.7±0.94.5±1.0−0.2 (−0.6 to 0.1)b
Ionized Ca, mg/dl−0.0 (−0.2 to 0.1)0.53
 Standard dialysate Mg4.6±0.24.6±0.3−0.1 (−0.1 to 0.0)
 High dialysate Mg4.6±0.44.5±0.3−0.0 (−0.1 to 0.0)
Fetuin-A, g/L0.01 (−0.03 to 0.05)0.55
 Standard dialysate Mg0.31±0.070.31±0.070.00 (−0.01 to 0.02)
 High dialysate Mg0.32±0.060.32±0.070.00 (−0.01 to 0.01)
HCO3, mEq/L−0 (−1 to 1)0.79
 Standard dialysate Mg25±225±20 (−0 to 1)
 High dialysate Mg24±325±21 (0 to 1)c
Albumin, g/dl0.0 (−0.2 to 0.2)0.87
 Standard dialysate Mg3.2±0.43.3±0.40.1 (−0.0 to 0.1)c
 High dialysate Mg3.3±0.33.3±0.40.0 (−0.1 to 0.1)
PTH, pg/ml−21% (−41% to 6%)0.12
 Standard dialysate Mg278 (199–359)311 (207–347)14% (1% to 28%)
 High dialysate Mg328 (206–387)238 (165–366)−21% (−28% to −13%)b
  • Baseline and follow-up values are described as mean±SD or median and interquartile range. Changes from baseline to follow-up are described as mean change with 95% CI. Change over time was analyzed using linear mixed models. Baseline was defined as the mean of measurements on days −7 and 0, and follow-up was defined as the mean of measurements on days 21 and 28. 95% CI, 95% confidence interval; T50, serum calcification propensity; Mg, magnesium; PO4, phosphate; Ca, calcium; HCO3, bicarbonate; PTH, intact parathyroid hormone.

  • a Change from baseline to end of follow-up is significant at P<0.001.

  • b Change from baseline to end of follow-up is significant at P<0.01.

  • c Change from baseline to end of follow-up is significant at P<0.05.