Table 4.

Patterns of illicit drug use, related medical conditions, and risk of kidney AA amyloidosis

CharacteristicComplete DataKidney AA Amyloidosis, n=38Other Kidney Diagnosis, n=72Odds Ratioa (95% Confidence Interval)
Any heroin use10835 (95)10 (14)169.5 (28.2 to 1018.2)b
 Recent use10728 (78)2 (3)222.6 (37.5 to 1322.8)b
 Intravenous use10830 (81)9 (13)37.0 (11.0 to 124.8)b
 Muscling10828 (76)0 (0)
 Skin popping10810 (27)0 (0)
Cocaine use11029 (76)14 (19)26.0 (7.5 to 89.9)b
Methamphetamine use1097 (18)5 (7)3.4 (0.9 to 12.5)
Skin abscess11033 (87)8 (11)64.7 (16.6 to 252.7)b
Endocarditis1105 (13)2 (3)6.9 (1.0 to 45.5)c
Bacteremia11028 (74)13 (18)20.0 (6.2 to 64.5)b
  • All values are expressed as number (percentage of nonmissing values). —, not applicable.

  • a Odds ratios adjusted for matching variables: age, race, sex, site, and calendar year of biopsy.

  • b P value<0.001.

  • c P value=0.05.