Table 2.

Factors associated with sodium correction >8 mEq/L at 24 hours in patients admitted to Geisinger system hospitals with an initial serum sodium <120 mEq/L

Variables	OR (95% CI)
Variables	Unadjusted	Model 1	Model 2	Model 3
Academic center	0.65 (0.53 to 0.81)^a	0.70 (0.54 to 0.90)^a	0.70 (0.52 to 0.94)^b	0.70 (0.54 to 0.91)^a
Women	1.34 (1.08 to 1.65)^a	1.49 (1.14 to 1.96)^a	1.73 (1.26 to 2.37)^a	1.50 (1.14 to 1.96)^a
Age, per 1 yr	0.98 (0.97 to 0.99)^a	0.98 (0.97 to 0.99)^a	0.98 (0.97 to 0.99)^a	0.98 (0.97 to 0.99)^a
White	1.03 (0.49 to 2.15)	1.03 (0.37 to 2.92)	0.74 (0.23 to 2.35)	1.01 (0.36 to 2.88)
Schizophrenia	2.73 (1.34 to 5.57)^a	2.24 (1.03 to 4.89)^b	2.48 (1.02 to 6.02)^b	2.24 (1.03 to 4.88)^b
Congestive heart failure	0.60 (0.45 to 0.81)^a	0.94 (0.66 to 1.33)	1.08 (0.72 to 1.63)	0.94 (0.67 to 1.34)
Charlson comorbidity index	0.86 (0.82 to 0.89)^a	0.94 (0.89 to 0.99)^b	0.93 (0.87 to 0.99)^b	0.94 (0.88 to 0.99)^b
Outpatient Na⁺ <135	0.52 (0.41 to 0.67)^a	0.62 (0.48 to 0.81)^a	0.62 (0.46 to 0.84)^a	0.62 (0.48 to 0.81)^a
Inpatient baseline Na⁺ at hospitalization	0.88 (0.86 to 0.91)^a	0.90 (0.87 to 0.93)^a	0.90 (0.87 to 0.93)^a	0.90 (0.87 to 0.93)^a
Urine Na⁺ <30 mEq/L	1.46 (1.15 to 1.85)^a		1.58 (1.17 to 2.13)^a
K⁺≥5 mEq/L	0.87 (0.66 to 1.16)	1.22 (0.88 to 1.71)	1.14 (0.76 to 1.70)	1.23 (0.87 to 1.74)
K⁺<3.5 mEq/L	1.81 (1.41 to 2.33)^a	1.32 (0.97 to 1.79)	1.39 (0.97 to 1.97)	1.24 (0.88 to 1.73)
Loop diuretics (outpatient)	0.42 (0.31 to 0.56)^a	0.71 (0.49 to 1.02)	0.66 (0.43 to 1.01)	0.71 (0.49 to 1.02)
Aldosterone antagonists (outpatient)	0.33 (0.21 to 0.52)^a	0.48 (0.28 to 0.82)^a	0.45 (0.23 to 0.84)^b	0.48 (0.28 to 0.83)^a
Hypertonic saline (inpatient)	2.03 (1.49 to 2.76)^a			1.09 (0.73 to 1.64)
Electrolyte repletion (inpatient)	1.71 (1.37 to 2.13^a			1.14 (0.84 to 1.55)
Vaptans (inpatient)	0.93 (0.36 to 2.41)			1.21 (0.40 to 3.63)
ICU stay in the first 24 h after admission	1.01 (0.78 to 1.30)			1.07 (0.79 to 1.44)

Model 1 included all significant unadjusted risk factors of rapid correction except for urine sodium or inpatient treatment factors. Model 2 included model 1 covariates and urine sodium (<30 or ≥30 mEq/L). Model 3 included model 1 covariates and inpatient treatment factors. OR, odds ratio; 95% CI, 95% confidence interval; Na⁺, sodium; K⁺, potassium; ICU, intensive care unit.
↵a Significant at P=0.01.
↵b Significant at P=0.05.