Table 4.

Reversal agents for oral anticoagulants and hemodialysis as an option to reverse antithrombotic effects

Reversal modalityWarfarinDabigatranRivaroxabanApixabanEdoxaban
Reversal by antidotes
 Prothrombin complex concentrateYesNoYesYesYes
 Recombinant factor VIIaYesNoYesYesYes
 Fresh frozen plasmaYesNoYesYesYes
 Factor VIII inhibitor bypass activityNot reportedYesYesYesYes
 Specific antidoteNoIdaracizumabInvestigational (andexanet alfa)
Dialysis as a treatment option for  major bleeding events
 HemodialysisNoYesNoNoNo