Table 3.

Common drug-drug interactions of oral anticoagulants

DrugIncrease Anticoagulant EffectsDecrease Anticoagulant Effects
WarfarinAmiodarone, fluconazole, tigecycline, voriconazole, fluoroquinolones, verapamil, diltiazem, other anticoagulants, antiplatelet drugs, NSAIDs, and SSRIsRifampin, phenobarbital, carbamazepine, cigarette smoking
DabigatranAmiodarone, verapamil, ketoconazole, dronaderone, clopidogrel, enoxaparin, other anticoagulants, antiplatelet drugsRifampin
ApixabanKetoconazole, other anticoagulants, antiplatelet drugsRifampin
RivaroxabanOther anticoagulants, antiplatelet drugs, fluconazole, ketoconazole, erythromycin, and clarithromycinRifampin, phenytoin, carbamazepine, St. John’s Wort
EdoxabanOther anticoagulants, antiplatelet drugs,Rifampin
  • NSAID, nonsteroidal anti-inflammatory drug; SSRI, serotonin reuptake inhibitor.