Table 1.

Common substrates for basolateral transporters of the proximal tubule

TransporterExample Substrates
Basolateral (gene symbol)
 OAT1 (SLC22A6) and OAT3 (SLC22A8)PAH, furosemide simvastatin, indoxyl sulfate
 OAT2 (SLC22A7)Salicylates, PG E2
 OCT2 (SLC22A2)Creatinine, metformin, cisplatin
Apical (gene symbol)
 OAT4 (SLC22A11)Tetracycline, captopril, methotrexate
 URAT1 (SLC22A12)Uric acid
 MRP2 (ABCC2)Folate, glycholate
  • OAT, organic anion transporter; SLC, solute carrier; PAH, p-aminohippurate; PG E2, prostaglandin E2; OCT, organic cation transporter.