Table 2.

Risk of outcomes among patients receiving direct oral anticoagulants versus warfarin, overall and stratified by eGFR

OutcomeNumber of EventsIR, per 100 PYsHR (95% CI)P ValueP-inter
Direct Oral AnticoagulantsWarfarinDirect Oral AnticoagulantsWarfarin
All bleeding (all/major/minor)
 Analyses 1
  Overall574/76/498607/126/48120.0/2.7/17.317.9/3.7/14.21.08 (0.97 to 1.22)0.16
  eGFR≥60350/39/311390/76/31417.3/1.9/15.416.8/3.3/13.51.01 (0.88 to 1.17)0.880.10
  eGFR<60224/37/187217/50/16726.3/4.4/21.920.1/4.6/15.51.23 (1.02 to 1.48)0.03
 Analyses 2
  Overall863/111/752805/155/65014.9/1.9/13.013.8/2.7/11.11.09 (0.99 to 1.20)0.08
  eGFR≥60537/63/474520/93/42712.9/1.5/11.412.7/2.3/10.41.03 (0.91 to 1.16)0.650.11
  eGFR<60326/48/278285/62/22320.0/2.9/17.116.3/3.6/12.71.21 (1.03 to 1.42)0.02
 Analyses 3
  Overall574/76/498740/142/74016.8/2.2/14.615.1/2.9/12.21.18 (1.05 to 1.31)0.004
  eGFR≥60350/39/311475/87/38814.7/1.6/13.014.1/2.6/11.51.11 (0.96 to 1.27)0.150.10
  eGFR<60224/37/187265/55/21021.8/3.6/18.217.2/3.6/13.61.33 (1.11 to 1.58)0.002
Ischemic stroke
 Analyses 1
  Overall2222446.96.60.97 (0.81 to 1.16)0.72
  eGFR≥601361526.06.00.94 (0.74 to 1.18)0.590.70
  eGFR<6086928.87.81.02 (0.76 to 1.37)0.91
 Analyses 2
  Overall3053014.44.51.00 (0.83 to 1.17)0.99
  eGFR≥601911934.04.20.97 (0.79 to 1.18)0.730.57
  eGFR<601141085.65.31.06 (0.82 to 1.38)0.64
 Analyses 3
  Overall2222826.96.00.94 (0.79 to 1.12)0.48
  eGFR≥601361806.15.60.89 (0.71 to 1.11)0.300.49
  eGFR<60861028.86.81.03 (0.77 to 1.37)0.85
  • Analyses 1: as-treated analyses; analyses 2: intention-to-treat analyses; analyses 3: time-varying analyses. IR, incidence rate; PY, person-years; HR, hazard ratio; 95% CI, 95% confidence interval; P-inter, P-for-interaction.